"Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease"
"Conclusions
—More than a quarter of the patients in ARISTOTLE with nonvalvular atrial fibrillation had moderate or severe valvular heart disease. There was no evidence of a differential effect of apixaban over warfarin in reducing stroke or systemic embolism, causing less bleeding, and reducing death in patients with and without valvular heart disease."
http://circ.ahajournals.org/content/132/8/624.abstract
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