Saturday, December 31, 2016
Wednesday, June 1, 2016
Research June 2016
ANNALS
"Variability in Pathologists' Interpretations of Individual Breast Biopsy Slides: A Population Perspective"
"Conclusion:
This analysis, based on interpretation of a single breast biopsy slide per case, predicts a low likelihood that a diagnosis of atypia or DCIS would be verified by a reference consensus diagnosis. This diagnostic grey zone should be considered in clinical management decisions in patients with these diagnoses."
http://annals.org/article.aspx?articleid=2505396
BMJ / Lancet
"One versus two years of elastic compression stockings for prevention of post-thrombotic syndrome (OCTAVIA study): randomised controlled trial"
"Conclusion
Stopping ECS after one year in compliant patients with proximal deep venous thrombosis seemed not to be non-inferior to continuing ECS therapy for two years in this non-inferiority trial."
http://www.bmj.com/content/353/bmj.i2691
CIRC / JACC
"Prepregnancy Diabetes and Offspring Risk of Congenital Heart Disease"
http://circ.ahajournals.org/content/133/23/2243.full
JAMA
"Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis"
"Conclusions and Relevance
Among children with mild gastroenteritis and minimal dehydration, initial oral hydration with dilute apple juice followed by their preferred fluids, compared with electrolyte maintenance solution, resulted in fewer treatment failures. In many high-income countries, the use of dilute apple juice and preferred fluids as desired may be an appropriate alternative to electrolyte maintenance fluids in children with mild gastroenteritis and minimal dehydration."
http://jama.jamanetwork.com/article.aspx?articleid=2518402
NEJM
"Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation"
http://www.nejm.org/doi/full/10.1056/NEJMoa1602014?query=featured_home
"Variability in Pathologists' Interpretations of Individual Breast Biopsy Slides: A Population Perspective"
"Conclusion:
This analysis, based on interpretation of a single breast biopsy slide per case, predicts a low likelihood that a diagnosis of atypia or DCIS would be verified by a reference consensus diagnosis. This diagnostic grey zone should be considered in clinical management decisions in patients with these diagnoses."
http://annals.org/article.aspx?articleid=2505396
BMJ / Lancet
"One versus two years of elastic compression stockings for prevention of post-thrombotic syndrome (OCTAVIA study): randomised controlled trial"
"Conclusion
Stopping ECS after one year in compliant patients with proximal deep venous thrombosis seemed not to be non-inferior to continuing ECS therapy for two years in this non-inferiority trial."
http://www.bmj.com/content/353/bmj.i2691
CIRC / JACC
"Prepregnancy Diabetes and Offspring Risk of Congenital Heart Disease"
http://circ.ahajournals.org/content/133/23/2243.full
JAMA
"Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis"
"Conclusions and Relevance
Among children with mild gastroenteritis and minimal dehydration, initial oral hydration with dilute apple juice followed by their preferred fluids, compared with electrolyte maintenance solution, resulted in fewer treatment failures. In many high-income countries, the use of dilute apple juice and preferred fluids as desired may be an appropriate alternative to electrolyte maintenance fluids in children with mild gastroenteritis and minimal dehydration."
http://jama.jamanetwork.com/article.aspx?articleid=2518402
NEJM
"Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation"
http://www.nejm.org/doi/full/10.1056/NEJMoa1602014?query=featured_home
Sunday, May 1, 2016
Research May 2016
ANNALS
"Gradual Versus Abrupt Smoking Cessation: A Randomized, Controlled Noninferiority Trial"
http://annals.org/article.aspx?articleid=2501853
"Long-Term Risk for Device-Related Complications and Reoperations After Implantable Cardioverter-Defibrillator Implantation"
http://annals.org/article.aspx?articleid=2520465
BMJ
"BMI and all cause mortality: systematic review and non-linear dose-response meta-analysis of 230 cohort studies with 3.74 million deaths among 30.3 million participants"
http://www.bmj.com/content/353/bmj.i2156
"Effect of age and sex on efficacy and tolerability of β blockers in patients with heart failure with reduced ejection fraction: individual patient data meta-analysis"
"Conclusion
Irrespective of age or sex, patients with HFrEF in sinus rhythm should receive β blockers to reduce the risk of death and admission to hospital."
http://www.bmj.com/content/353/bmj.i1855
CIRC / JACC
"Reduced Cardiac Index Is Not the Dominant Driver of Renal Dysfunction in Heart Failure"
http://content.onlinejacc.org/article.aspx?articleID=2520902
"Diabetes Mellitus and Prevention of Late Myocardial Infarction After Coronary Stenting in the Randomized Dual Antiplatelet Therapy Study"
http://circ.ahajournals.org/content/133/18/1772.full
JAMA
"Effect of Using the Same vs Different Order for Second Readings of Screening Mammograms on Rates of Breast Cancer Detection"
"Conclusions and Relevance Interpretation of batches of mammograms by qualified screening mammography readers using a different order vs the same order for the second reading resulted in no significant difference in rates of detection of breast cancer."
http://jama.jamanetwork.com/article.aspx?articleid=2520628
"Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011"
http://jama.jamanetwork.com/article.aspx?articleid=2518263
NEJM
"Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest"
http://www.nejm.org/doi/full/10.1056/NEJMoa1514204?query=featured_home
"Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit'
http://www.nejm.org/doi/full/10.1056/NEJMoa1603017?query=featured_home
"Gradual Versus Abrupt Smoking Cessation: A Randomized, Controlled Noninferiority Trial"
http://annals.org/article.aspx?articleid=2501853
"Long-Term Risk for Device-Related Complications and Reoperations After Implantable Cardioverter-Defibrillator Implantation"
http://annals.org/article.aspx?articleid=2520465
BMJ
"BMI and all cause mortality: systematic review and non-linear dose-response meta-analysis of 230 cohort studies with 3.74 million deaths among 30.3 million participants"
http://www.bmj.com/content/353/bmj.i2156
"Effect of age and sex on efficacy and tolerability of β blockers in patients with heart failure with reduced ejection fraction: individual patient data meta-analysis"
"Conclusion
Irrespective of age or sex, patients with HFrEF in sinus rhythm should receive β blockers to reduce the risk of death and admission to hospital."
http://www.bmj.com/content/353/bmj.i1855
CIRC / JACC
"Reduced Cardiac Index Is Not the Dominant Driver of Renal Dysfunction in Heart Failure"
http://content.onlinejacc.org/article.aspx?articleID=2520902
"Diabetes Mellitus and Prevention of Late Myocardial Infarction After Coronary Stenting in the Randomized Dual Antiplatelet Therapy Study"
http://circ.ahajournals.org/content/133/18/1772.full
JAMA
"Effect of Using the Same vs Different Order for Second Readings of Screening Mammograms on Rates of Breast Cancer Detection"
"Conclusions and Relevance Interpretation of batches of mammograms by qualified screening mammography readers using a different order vs the same order for the second reading resulted in no significant difference in rates of detection of breast cancer."
http://jama.jamanetwork.com/article.aspx?articleid=2520628
"Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011"
http://jama.jamanetwork.com/article.aspx?articleid=2518263
NEJM
"Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest"
http://www.nejm.org/doi/full/10.1056/NEJMoa1514204?query=featured_home
"Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit'
http://www.nejm.org/doi/full/10.1056/NEJMoa1603017?query=featured_home
Guidelines May 2016
May 26, 2016
"2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease"
http://circ.ahajournals.org/content/early/2016/03/28/CIR.0000000000000404
"Duration of Dual Antiplatelet Therapy: A Systematic Review for the 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease"
http://circ.ahajournals.org/content/early/2016/03/28/CIR.0000000000000405
--------------
May 19, 2016
"Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High-Value Care From the American College of Physicians and the Centers for Disease Control and Prevention"
http://annals.org/article.aspx?articleid=2481815
---------------
May 12, 2016
"Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement"
http://annals.org/article.aspx?articleid=2513179
--------------
May 5, 2016
"AHA Scientific Statement Electrocardiographic Early Repolarization"
http://circ.ahajournals.org/content/133/15/1520.full
"The early repolarization (ER) pattern (ERP), initially described as elevation of the ST segment of ≥1 leads on the 12-lead ECG, has long been considered a benign phenomenon. However, more recent studies have demonstrated positive, negative, and neutral associations between an ERP and various end points, including all-cause, cardiac, and arrhythmic mortality. These recent studies have used more complex or heterogeneous definitions of ER, including J-wave or J-point elevation and QRS complex notching or slurring, with or without concomitant ST-segment elevation. Other studies have identified an increased prevalence of ERP in survivors of spontaneous ventricular fibrillation (VF) or cardiac arrest."
"2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease"
http://circ.ahajournals.org/content/early/2016/03/28/CIR.0000000000000404
"Duration of Dual Antiplatelet Therapy: A Systematic Review for the 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease"
http://circ.ahajournals.org/content/early/2016/03/28/CIR.0000000000000405
--------------
May 19, 2016
"Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High-Value Care From the American College of Physicians and the Centers for Disease Control and Prevention"
http://annals.org/article.aspx?articleid=2481815
---------------
May 12, 2016
"Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement"
http://annals.org/article.aspx?articleid=2513179
--------------
May 5, 2016
"AHA Scientific Statement Electrocardiographic Early Repolarization"
http://circ.ahajournals.org/content/133/15/1520.full
"The early repolarization (ER) pattern (ERP), initially described as elevation of the ST segment of ≥1 leads on the 12-lead ECG, has long been considered a benign phenomenon. However, more recent studies have demonstrated positive, negative, and neutral associations between an ERP and various end points, including all-cause, cardiac, and arrhythmic mortality. These recent studies have used more complex or heterogeneous definitions of ER, including J-wave or J-point elevation and QRS complex notching or slurring, with or without concomitant ST-segment elevation. Other studies have identified an increased prevalence of ERP in survivors of spontaneous ventricular fibrillation (VF) or cardiac arrest."
Friday, April 1, 2016
Research Review April 2016
ANNALS:
"The Effect of Erythropoietin-Stimulating Agents on Health-Related Quality of Life in Anemia of Chronic Kidney Disease: A Systematic Review and Meta-analysis"
http://annals.org/article.aspx?articleid=2491918
"Relationship Among Body Fat Percentage, Body Mass Index, and All-Cause Mortality: A Cohort Study" http://annals.org/article.aspx?articleid=2499472
====================================================
BMJ:
"Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic drugs for rheumatoid arthritis: abridged Cochrane systematic review and network meta-analysis"
http://www.bmj.com/content/353/bmj.i1777
"Defibrillation time intervals and outcomes of cardiac arrest in hospital: retrospective cohort study from Get With The Guidelines-Resuscitation registry"
http://www.bmj.com/content/353/bmj.i1653
====================================================
CIRC:
REVIEW:
"Peripartum Cardiomyopathy"
http://circ.ahajournals.org/content/133/14/1397.full
"Individualized Statin Benefit for Determining Statin Eligibility in the Primary Prevention of Cardiovascular Disease"
http://circ.ahajournals.org/content/133/16/1574.abstract
====================================================
JAMA:
"Effect of Postextubation High-Flow Nasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients"
https://jama.jamanetwork.com/article.aspx?articleid=2503420
"Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction"
https://jama.jamanetwork.com/article.aspx?articleid=2511223
====================================================
NEJM:
"Fresh Fruit Consumption and Major Cardiovascular Disease in China" http://www.nejm.org/doi/full/10.1056/NEJMoa1501451
"CONCLUSIONS Among Chinese adults, a higher level of fruit consumption was associated with lower blood pressure and blood glucose levels and, largely independent of these and other dietary and nondietary factors, with significantly lower risks of major cardiovascular diseases. "
"Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure" http://www.nejm.org/doi/full/10.1056/NEJMoa1514859
"CONCLUSIONS In patients with chronic heart failure, the addition of aliskiren to enalapril led to more adverse events without an increase in benefit. Noninferiority was not shown for aliskiren as compared with enalapril. (Funded by Novartis; ATMOSPHERE ClinicalTrials.gov number,NCT00853658.)"
"The Effect of Erythropoietin-Stimulating Agents on Health-Related Quality of Life in Anemia of Chronic Kidney Disease: A Systematic Review and Meta-analysis"
http://annals.org/article.aspx?articleid=2491918
"Relationship Among Body Fat Percentage, Body Mass Index, and All-Cause Mortality: A Cohort Study" http://annals.org/article.aspx?articleid=2499472
====================================================
BMJ:
"Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic drugs for rheumatoid arthritis: abridged Cochrane systematic review and network meta-analysis"
http://www.bmj.com/content/353/bmj.i1777
"Defibrillation time intervals and outcomes of cardiac arrest in hospital: retrospective cohort study from Get With The Guidelines-Resuscitation registry"
http://www.bmj.com/content/353/bmj.i1653
====================================================
CIRC:
REVIEW:
"Peripartum Cardiomyopathy"
http://circ.ahajournals.org/content/133/14/1397.full
"Individualized Statin Benefit for Determining Statin Eligibility in the Primary Prevention of Cardiovascular Disease"
http://circ.ahajournals.org/content/133/16/1574.abstract
====================================================
JAMA:
"Effect of Postextubation High-Flow Nasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients"
https://jama.jamanetwork.com/article.aspx?articleid=2503420
"Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction"
https://jama.jamanetwork.com/article.aspx?articleid=2511223
====================================================
NEJM:
"Fresh Fruit Consumption and Major Cardiovascular Disease in China" http://www.nejm.org/doi/full/10.1056/NEJMoa1501451
"CONCLUSIONS Among Chinese adults, a higher level of fruit consumption was associated with lower blood pressure and blood glucose levels and, largely independent of these and other dietary and nondietary factors, with significantly lower risks of major cardiovascular diseases. "
"Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure" http://www.nejm.org/doi/full/10.1056/NEJMoa1514859
"CONCLUSIONS In patients with chronic heart failure, the addition of aliskiren to enalapril led to more adverse events without an increase in benefit. Noninferiority was not shown for aliskiren as compared with enalapril. (Funded by Novartis; ATMOSPHERE ClinicalTrials.gov number,NCT00853658.)"
Guidelines April 2016
April 29, 2016
"AHA Scientific Statement Acute Myocardial Infarction in Women
A Scientific Statement From the American Heart Association"
http://circ.ahajournals.org/content/133/9/916
---------------
April 22, 2016
"Diagnosis and Management of Diabetes: Synopsis of the 2016 American Diabetes Association Standards of Medical Care in Diabetes"
http://annals.org/article.aspx?articleid=2498492
--------------
April 15, 2016
"Hematuria as a Marker of Occult Urinary Tract Cancer: Advice for High-Value Care From the American College of Physicians"
http://annals.org/article.aspx?articleid=2484287
--------------
April 8, 2016
"2015 International Consensus on First Aid Science With Treatment Recommendations
Part 9: First Aid"
http://circ.ahajournals.org/content/132/16_suppl_1/S269.full
--------------
April 1, 2016
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 8: Education, Implementation, and Teams"
http://circ.ahajournals.org/content/132/16_suppl_1/S242.full
"AHA Scientific Statement Acute Myocardial Infarction in Women
A Scientific Statement From the American Heart Association"
http://circ.ahajournals.org/content/133/9/916
---------------
April 22, 2016
"Diagnosis and Management of Diabetes: Synopsis of the 2016 American Diabetes Association Standards of Medical Care in Diabetes"
http://annals.org/article.aspx?articleid=2498492
--------------
April 15, 2016
"Hematuria as a Marker of Occult Urinary Tract Cancer: Advice for High-Value Care From the American College of Physicians"
http://annals.org/article.aspx?articleid=2484287
--------------
April 8, 2016
"2015 International Consensus on First Aid Science With Treatment Recommendations
Part 9: First Aid"
http://circ.ahajournals.org/content/132/16_suppl_1/S269.full
--------------
April 1, 2016
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 8: Education, Implementation, and Teams"
http://circ.ahajournals.org/content/132/16_suppl_1/S242.full
Tuesday, March 1, 2016
Guidelines March 2016
Dates reflect the EvidMed listing date, not the guideline publication date
March 25, 2016
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 7: Neonatal Resuscitation"
http://circ.ahajournals.org/content/132/16_suppl_1/S204.full
-----------------
March 18, 2016
March 11, 2016:
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 5: Acute Coronary Syndromes"
http://circ.ahajournals.org/content/132/16_suppl_1/S146.full
-------------------
March 4, 2016:
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 4: Advanced Life Support"
http://circ.ahajournals.org/content/132/16_suppl_1/S84.full
March 25, 2016
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 7: Neonatal Resuscitation"
http://circ.ahajournals.org/content/132/16_suppl_1/S204.full
-----------------
March 18, 2016
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 6: Pediatric Basic Life Support and Pediatric Advanced Life Support"
http://circ.ahajournals.org/content/132/16_suppl_1/S177.full
------------------Part 6: Pediatric Basic Life Support and Pediatric Advanced Life Support"
http://circ.ahajournals.org/content/132/16_suppl_1/S177.full
March 11, 2016:
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 5: Acute Coronary Syndromes"
http://circ.ahajournals.org/content/132/16_suppl_1/S146.full
-------------------
March 4, 2016:
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 4: Advanced Life Support"
http://circ.ahajournals.org/content/132/16_suppl_1/S84.full
Research Review March 2016
JAMA
"Developing a New Definition and Assessing New Clinical Criteria for Septic Shock
For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)"
http://jama.jamanetwork.com/article.aspx?articleid=2492876
"High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery"
https://jama.jamanetwork.com/article.aspx?articleid=2492851
NEJM
"Stopping vs. Continuing Aspirin before Coronary Artery Surgery"
http://www.nejm.org/doi/full/10.1056/NEJMoa1507688?query=featured_home
"Randomized Trial of Labor Induction in Women 35 Years of Age or Older"
http://www.nejm.org/doi/full/10.1056/NEJMoa1509117
BMJ
"Oral fluoroquinolone use and serious arrhythmia: bi-national cohort study"
http://www.bmj.com/content/352/bmj.i843
"Primary prevention and risk factor reduction in coronary heart disease mortality among working aged men and women in eastern Finland over 40 years: population based observational study"
http://www.bmj.com/content/352/bmj.i721
CIRC
"Herpesvirus Infections and Childhood Arterial Ischemic Stroke Results of the VIPS Study"
http://circ.ahajournals.org/content/133/8/732.full
"Alcohol and Immediate Risk of Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis"
http://circ.ahajournals.org/content/early/2016/02/29/CIRCULATIONAHA.115.019743.abstract
"Developing a New Definition and Assessing New Clinical Criteria for Septic Shock
For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)"
http://jama.jamanetwork.com/article.aspx?articleid=2492876
"High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery"
https://jama.jamanetwork.com/article.aspx?articleid=2492851
NEJM
"Stopping vs. Continuing Aspirin before Coronary Artery Surgery"
http://www.nejm.org/doi/full/10.1056/NEJMoa1507688?query=featured_home
"Randomized Trial of Labor Induction in Women 35 Years of Age or Older"
http://www.nejm.org/doi/full/10.1056/NEJMoa1509117
BMJ
"Oral fluoroquinolone use and serious arrhythmia: bi-national cohort study"
http://www.bmj.com/content/352/bmj.i843
"Primary prevention and risk factor reduction in coronary heart disease mortality among working aged men and women in eastern Finland over 40 years: population based observational study"
http://www.bmj.com/content/352/bmj.i721
CIRC
"Herpesvirus Infections and Childhood Arterial Ischemic Stroke Results of the VIPS Study"
http://circ.ahajournals.org/content/133/8/732.full
"Alcohol and Immediate Risk of Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis"
http://circ.ahajournals.org/content/early/2016/02/29/CIRCULATIONAHA.115.019743.abstract
Sunday, February 28, 2016
Guidelines Feb 2016
Feb 26, 2016
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 3: Adult Basic Life Support and Automated External Defibrillation"
http://circ.ahajournals.org/content/132/16_suppl_1/S51.full
---------------
Feb 19, 2016
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 2: Evidence Evaluation and Management of Conflicts of Interest"
http://circ.ahajournals.org/content/132/16_suppl_1/S40.full
---------------
Feb 12, 2016
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 1: Executive Summary"
http://circ.ahajournals.org/content/132/16_suppl_1/S2.full
-----------------
Feb 5, 2016
2015 AHA / ACC:
"Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 5:
Valvular Heart Disease: A Scientific Statement From the American Heart Association and American College of Cardiology"
http://circ.ahajournals.org/content/132/22/e292.full.pdf+html
Research Review - Feb 2016
JAMA
"Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents"
==========
NEJM
Lancet - "Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: complete follow-up results from the CHAMPION randomised trial"
==========
CIRC
CIRC - "Atrial Fibrillation Begets Heart Failure and Vice Versa"
http://circ.ahajournals.org/content/133/5/484.abstract
"Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents"
==========
NEJM
NEJM - "National Cluster-Randomized Trial of Duty-Hour Flexibility in Surgical Training"
http://www.nejm.org/doi/full/10.1056/NEJMoa1515724?query=featured_home
==========
BMJ / Lancethttp://www.nejm.org/doi/full/10.1056/NEJMoa1515724?query=featured_home
==========
Lancet - "Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: complete follow-up results from the CHAMPION randomised trial"
==========
CIRC
CIRC - "Atrial Fibrillation Begets Heart Failure and Vice Versa"
http://circ.ahajournals.org/content/133/5/484.abstract
Guidelines - Jan 2016
Jan 29, 2016
"AHA/ACC Scientific Statement
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 4: Congenital Heart Disease"
http://circ.ahajournals.org/content/132/22/e281.full
-----------------------
Jan 22, 2016
"AHA/ACC Scientific Statement
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 3: Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy and Other Cardiomyopathies, and Myocarditis"
http://circ.ahajournals.org/content/132/22/e273.full
---------------------
Jan 15, 2016
"AHA/ACC Scientific Statement Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 2: Preparticipation Screening for Cardiovascular Disease in Competitive Athletes"
http://circ.ahajournals.org/content/132/22/e267.full
----------------------
Jan 8, 2016
"AHA/ACC Scientific Statement
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 1: Classification of Sports: Dynamic, Static, and Impact"
http://circ.ahajournals.org/content/132/22/e262
-----------------
Jan 1, 2016
"AHA Scientific Statement
The Agenda for Familial Hypercholesterolemia"
http://circ.ahajournals.org/content/132/22/2167
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 1: Classification of Sports: Dynamic, Static, and Impact"
http://circ.ahajournals.org/content/132/22/e262
-----------------
Jan 1, 2016
"AHA Scientific Statement
The Agenda for Familial Hypercholesterolemia"
http://circ.ahajournals.org/content/132/22/2167
Research Review - Jan 2016
JAMA
"Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease"
"Conclusions and Relevance Among adult patients with refractory Crohn disease not amenable to surgery who had impaired quality of life, HSCT, compared with conventional therapy, did not result in a statistically significant improvement in sustained disease remission at 1 year and was associated with significant toxicity. These findings do not support the widespread use of HSCT for patients with refractory Crohn disease."
http://jama.jamanetwork.com/article.aspx?articleid=2475462
"Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection" "Conclusions and Relevance Among adults with recurrent or refractory CDI, the use of frozen compared with fresh FMT did not result in worse proportion of clinical resolution of diarrhea. Given the potential advantages of providing frozen FMT, its use is a reasonable option in this setting."
http://jama.jamanetwork.com/article.aspx?articleid=2481003
==========
NEJM
"Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection"
"CONCLUSIONS
==========
BMJ / Lancet
BMJ: "Nosocomial transmission of avian influenza A (H7N9) virus in China: epidemiological investigation"
"What this study adds
Nosocomial H7N9 transmission might be possible between two unrelated individuals. Surveillance on patients with influenza-like illness in hospitals as well as chickens in live poultry markets should be enhanced to monitor transmissibility and pathogenicity of the virus."
http://www.bmj.com/content/351/bmj.h5765
Lancet: "Continued versus discontinued cannabis use in patients with psychosis: a systematic review and meta-analysis"
"Interpretation Continued cannabis use after onset of psychosis predicts adverse outcome, including higher relapse rates, longer hospital admissions, and more severe positive symptoms than for individuals who discontinue cannabis use and those who are non-users. These findings point to reductions in cannabis use as a crucial interventional target to improve outcome in patients with psychosis." http://lancet.com/journals/lanpsy/article/PIIS2215-0366(15)00363-6/abstract
===========
CIRC
"Hypertrophic Cardiomyopathy in Children, Adolescents, and Young Adults Associated With Low Cardiovascular Mortality With Contemporary Management Strategies"
"Conclusions—In a large hospital-based cohort of young HCM patients, representing an age group considered at greatest risk, low mortality rates can be achieved with the application of contemporary cardiovascular treatment strategies, largely because of reliable identification of high-risk patients who benefited from implantable cardioverter-defibrillators for sudden death prevention, thereby creating the opportunity for extended longevity and good quality of life."
http://circ.ahajournals.org/content/133/1/62.abstract
"Physical Activity and Risk of Coronary Heart Disease and Stroke in Older Adults The Cardiovascular Health Study"
"Conclusions—These data provide empirical evidence supporting PA recommendations, in particular, walking, to reduce the incidence of CVD among older adults." http://circ.ahajournals.org/content/133/2/147.abstract
"Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease"
"Conclusions and Relevance Among adult patients with refractory Crohn disease not amenable to surgery who had impaired quality of life, HSCT, compared with conventional therapy, did not result in a statistically significant improvement in sustained disease remission at 1 year and was associated with significant toxicity. These findings do not support the widespread use of HSCT for patients with refractory Crohn disease."
http://jama.jamanetwork.com/article.aspx?articleid=2475462
"Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection" "Conclusions and Relevance Among adults with recurrent or refractory CDI, the use of frozen compared with fresh FMT did not result in worse proportion of clinical resolution of diarrhea. Given the potential advantages of providing frozen FMT, its use is a reasonable option in this setting."
http://jama.jamanetwork.com/article.aspx?articleid=2481003
==========
NEJM
"Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection"
"CONCLUSIONS
Once-daily sofosbuvir–velpatasvir for 12 weeks provided high rates of sustained virologic response among both previously treated and untreated patients infected with HCV genotype 1, 2, 4, 5, or 6, including those with compensated cirrhosis. (Funded by Gilead Sciences; ClinicalTrials.gov number, NCT02201940.)" http://www.nejm.org/doi/full/10.1056/NEJMoa1512610?query=featured_home
REVIEW:
"Relationship between Nonmedical Prescription-Opioid Use and Heroin Use"
"The nonmedical use of prescription opioids is a major public health issue in the United States, both because of the overall high prevalence and because of marked increases in associated morbidity and mortality.1 In 2014, a total of 10.3 million persons reported using prescription opioids nonmedically (i.e., using medications that were not prescribed for them or were taken only for the experience or feeling that they caused).2 Emergency department visits involving misuse or abuse of prescription opioids increased 153% between 2004 and 2011, and admissions to substance-abuse treatment programs linked to prescription opioids more than quadrupled between 2002 and 2012.3,4Most troubling, between 2000 and 2014 the rates of death from prescription-opioid overdose nearly quadrupled (from 1.5 to 5.9 deaths per 100,000 persons) (Figure 1)."
http://www.nejm.org/doi/full/10.1056/NEJMra1508490?query=featured_home
REVIEW:
"Relationship between Nonmedical Prescription-Opioid Use and Heroin Use"
"The nonmedical use of prescription opioids is a major public health issue in the United States, both because of the overall high prevalence and because of marked increases in associated morbidity and mortality.1 In 2014, a total of 10.3 million persons reported using prescription opioids nonmedically (i.e., using medications that were not prescribed for them or were taken only for the experience or feeling that they caused).2 Emergency department visits involving misuse or abuse of prescription opioids increased 153% between 2004 and 2011, and admissions to substance-abuse treatment programs linked to prescription opioids more than quadrupled between 2002 and 2012.3,4Most troubling, between 2000 and 2014 the rates of death from prescription-opioid overdose nearly quadrupled (from 1.5 to 5.9 deaths per 100,000 persons) (Figure 1)."
http://www.nejm.org/doi/full/10.1056/NEJMra1508490?query=featured_home
==========
BMJ / Lancet
BMJ: "Nosocomial transmission of avian influenza A (H7N9) virus in China: epidemiological investigation"
"What this study adds
Nosocomial H7N9 transmission might be possible between two unrelated individuals. Surveillance on patients with influenza-like illness in hospitals as well as chickens in live poultry markets should be enhanced to monitor transmissibility and pathogenicity of the virus."
http://www.bmj.com/content/351/bmj.h5765
Lancet: "Continued versus discontinued cannabis use in patients with psychosis: a systematic review and meta-analysis"
"Interpretation Continued cannabis use after onset of psychosis predicts adverse outcome, including higher relapse rates, longer hospital admissions, and more severe positive symptoms than for individuals who discontinue cannabis use and those who are non-users. These findings point to reductions in cannabis use as a crucial interventional target to improve outcome in patients with psychosis." http://lancet.com/journals/lanpsy/article/PIIS2215-0366(15)00363-6/abstract
===========
CIRC
"Hypertrophic Cardiomyopathy in Children, Adolescents, and Young Adults Associated With Low Cardiovascular Mortality With Contemporary Management Strategies"
"Conclusions—In a large hospital-based cohort of young HCM patients, representing an age group considered at greatest risk, low mortality rates can be achieved with the application of contemporary cardiovascular treatment strategies, largely because of reliable identification of high-risk patients who benefited from implantable cardioverter-defibrillators for sudden death prevention, thereby creating the opportunity for extended longevity and good quality of life."
http://circ.ahajournals.org/content/133/1/62.abstract
"Physical Activity and Risk of Coronary Heart Disease and Stroke in Older Adults The Cardiovascular Health Study"
"Conclusions—These data provide empirical evidence supporting PA recommendations, in particular, walking, to reduce the incidence of CVD among older adults." http://circ.ahajournals.org/content/133/2/147.abstract
Friday, February 26, 2016
Weekly Guideline
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 3: Adult Basic Life Support and Automated External Defibrillation"
http://circ.ahajournals.org/content/132/16_suppl_1/S51.full
Part 3: Adult Basic Life Support and Automated External Defibrillation"
http://circ.ahajournals.org/content/132/16_suppl_1/S51.full
Thursday, February 25, 2016
CIRC - "Herpesvirus Infections and Childhood Arterial Ischemic Stroke Results of the VIPS Study"
"Herpesvirus Infections and Childhood Arterial Ischemic Stroke Results of the VIPS Study"
"Conclusions—Herpesviruses may act as a trigger for childhood AIS, even if the infection is subclinical. Antivirals like acyclovir might have a role in the prevention of recurrent stroke if further studies confirm a causal relationship."
http://circ.ahajournals.org/content/133/8/732.full
"Conclusions—Herpesviruses may act as a trigger for childhood AIS, even if the infection is subclinical. Antivirals like acyclovir might have a role in the prevention of recurrent stroke if further studies confirm a causal relationship."
http://circ.ahajournals.org/content/133/8/732.full
Wednesday, February 24, 2016
BMJ - "Oral fluoroquinolone use and serious arrhythmia: bi-national cohort study"
BMJ - "Oral fluoroquinolone use and serious arrhythmia: bi-national cohort study"
"Conclusions
Contrary to previous reports, oral fluoroquinolone treatment was not associated with an increased risk of serious arrhythmia in the general adult populations of Denmark and Sweden. Given the statistical power of the study, even small increases in relative and absolute risk could be ruled out. Since ciprofloxacin was the most commonly used fluoroquinolone in our study, we cannot exclude that intraclass differences influence the risk of serious arrhythmia associated with other less frequently used fluoroquinolones."
http://www.bmj.com/content/352/bmj.i843
"Conclusions
Contrary to previous reports, oral fluoroquinolone treatment was not associated with an increased risk of serious arrhythmia in the general adult populations of Denmark and Sweden. Given the statistical power of the study, even small increases in relative and absolute risk could be ruled out. Since ciprofloxacin was the most commonly used fluoroquinolone in our study, we cannot exclude that intraclass differences influence the risk of serious arrhythmia associated with other less frequently used fluoroquinolones."
http://www.bmj.com/content/352/bmj.i843
Tuesday, February 23, 2016
NEJM - "Effects of Testosterone Treatment in Older Men"
"Effects of Testosterone Treatment in Older Men"
http://www.nejm.org/doi/full/10.1056/NEJMoa1506119
"CONCLUSIONS
In symptomatic men 65 years of age or older, raising testosterone concentrations for 1 year from moderately low to the mid-normal range for men 19 to 40 years of age had a moderate benefit with respect to sexual function and some benefit with respect to mood and depressive symptoms but no benefit with respect to vitality or walking distance. The number of participants was too few to draw conclusions about the risks of testosterone treatment. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number,NCT00799617.)
http://www.nejm.org/doi/full/10.1056/NEJMoa1506119
Monday, February 22, 2016
JAMA - "Effect of Behavioral Interventions on Inappropriate Antibiotic Prescribing Among Primary Care Practices"
JAMA - "Effect of Behavioral Interventions on Inappropriate Antibiotic Prescribing Among Primary Care Practices"
"Conclusions and Relevance Among primary care practices, the use of accountable justification and peer comparison as behavioral interventions resulted in lower rates of inappropriate antibiotic prescribing for acute respiratory tract infections."
http://jama.jamanetwork.com/article.aspx?articleid=2488307
"Conclusions and Relevance Among primary care practices, the use of accountable justification and peer comparison as behavioral interventions resulted in lower rates of inappropriate antibiotic prescribing for acute respiratory tract infections."
http://jama.jamanetwork.com/article.aspx?articleid=2488307
Friday, February 19, 2016
Weekly Guideline
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 2: Evidence Evaluation and Management of Conflicts of Interest"
http://circ.ahajournals.org/content/132/16_suppl_1/S40.full
Part 2: Evidence Evaluation and Management of Conflicts of Interest"
http://circ.ahajournals.org/content/132/16_suppl_1/S40.full
Thursday, February 18, 2016
CIRC - "Periodontitis Increases the Risk of a First Myocardial Infarction"
"Periodontitis Increases the Risk of a First Myocardial Infarction"
"Conclusions—In this large case–control study of PD, verified by radiographic bone loss and with a careful consideration of potential confounders, the risk of a first MI was significantly increased in patients with PD even after adjustment for confounding factors. These findings strengthen the possibility of an independent relationship between PD and MI."
http://circ.ahajournals.org/content/133/6/576.abstract
"Conclusions—In this large case–control study of PD, verified by radiographic bone loss and with a careful consideration of potential confounders, the risk of a first MI was significantly increased in patients with PD even after adjustment for confounding factors. These findings strengthen the possibility of an independent relationship between PD and MI."
http://circ.ahajournals.org/content/133/6/576.abstract
Wednesday, February 17, 2016
BMJ - "Maternal use of oral contraceptives and risk of birth defects in Denmark: prospective, nationwide cohort study"
"Maternal use of oral contraceptives and risk of birth defects in Denmark: prospective, nationwide cohort study"
"What this study adds Oral contraceptive exposure just before or during pregnancy does not appear to be associated with an increased risk of major birth defects."
http://www.bmj.com/content/352/bmj.h6712
"What this study adds Oral contraceptive exposure just before or during pregnancy does not appear to be associated with an increased risk of major birth defects."
http://www.bmj.com/content/352/bmj.h6712
Tuesday, February 16, 2016
NEJM - "Incidence of Dementia over Three Decades in the Framingham Heart Study"
"Incidence of Dementia over Three Decades in the Framingham Heart Study"
""CONCLUSIONS
""CONCLUSIONS
Among participants in the Framingham Heart Study, the incidence of dementia has declined over the course of three decades. The factors contributing to this decline have not been completely identified. (Funded by the National Institutes of Health.)"
http://www.nejm.org/doi/full/10.1056/NEJMoa1504327
Monday, February 15, 2016
JAMA - "Association of Admission to Veterans Affairs Hospitals vs Non–Veterans Affairs Hospitals With Mortality and Readmission Rates Among Older Men Hospitalized With Acute Myocardial Infarction, Heart Failure, or Pneumonia"
"Association of Admission to Veterans Affairs Hospitals vs Non–Veterans Affairs Hospitals With Mortality and Readmission Rates Among Older Men Hospitalized With Acute Myocardial Infarction, Heart Failure, or Pneumonia"
"Conclusions and Relevance Among older men with AMI, HF, or pneumonia, hospitalization at VA hospitals, compared with hospitalization at non-VA hospitals, was associated with lower 30-day risk-standardized all-cause mortality rates for AMI and HF, and higher 30-day risk-standardized all-cause readmission rates for all 3 conditions, both nationally and within similar geographic areas, although absolute differences between these outcomes at VA and non-VA hospitals were small."
http://jama.jamanetwork.com/article.aspx?articleid=2488309
"Conclusions and Relevance Among older men with AMI, HF, or pneumonia, hospitalization at VA hospitals, compared with hospitalization at non-VA hospitals, was associated with lower 30-day risk-standardized all-cause mortality rates for AMI and HF, and higher 30-day risk-standardized all-cause readmission rates for all 3 conditions, both nationally and within similar geographic areas, although absolute differences between these outcomes at VA and non-VA hospitals were small."
http://jama.jamanetwork.com/article.aspx?articleid=2488309
Friday, February 12, 2016
Weekly Guideline - "2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations Part 1: Executive Summary"
"2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Part 1: Executive Summary"
http://circ.ahajournals.org/content/132/16_suppl_1/S2.full
Part 1: Executive Summary"
http://circ.ahajournals.org/content/132/16_suppl_1/S2.full
Tuesday, February 9, 2016
NEJM - "Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus"
"Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus"
""CONCLUSIONS
""CONCLUSIONS
Among women without diabetes who had a BMI of more than 35, the antenatal administration of metformin reduced maternal weight gain but not neonatal birth weight. (Funded by the Fetal Medicine Foundation; ClinicalTrials.gov number, NCT01273584; EudraCT number, 2008-005892-83.)"
http://www.nejm.org/doi/full/10.1056/NEJMoa1509819
Monday, February 8, 2016
JAMA - "Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults"
JAMA "Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults"
"Conclusions and Relevance In cross-sectional analyses, moderate seafood consumption was correlated with lesser Alzheimer disease neuropathology. Although seafood consumption was also correlated with higher brain levels of mercury, these levels were not correlated with brain neuropathology."
https://jama.jamanetwork.com/article.aspx?articleid=2484683
"Conclusions and Relevance In cross-sectional analyses, moderate seafood consumption was correlated with lesser Alzheimer disease neuropathology. Although seafood consumption was also correlated with higher brain levels of mercury, these levels were not correlated with brain neuropathology."
https://jama.jamanetwork.com/article.aspx?articleid=2484683
Friday, February 5, 2016
Weekly Guideline - "Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 5: Valvular Heart Disease: A Scientific Statement From the American Heart Association and American College of Cardiology"
Weekly Guideline -
"Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 5:
Valvular Heart Disease: A Scientific Statement From the American Heart Association and American College of Cardiology"
http://circ.ahajournals.org/content/132/22/e292.full.pdf+html
"Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 5:
Valvular Heart Disease: A Scientific Statement From the American Heart Association and American College of Cardiology"
http://circ.ahajournals.org/content/132/22/e292.full.pdf+html
Thursday, February 4, 2016
CIRC - "Atrial Fibrillation Begets Heart Failure and Vice Versa"
CIRC - "Atrial Fibrillation Begets Heart Failure and Vice Versa"
"Conclusions
—AF occurs in more than half of individuals with HF, and HF occurs in more than one third of individuals with AF. AF precedes and follows HF with both preserved and reduced ejection fraction, with some differences in temporal association and prognosis. Future studies focused on underlying mechanisms of these dual conditions are warranted."
http://circ.ahajournals.org/content/133/5/484.abstract
"Conclusions
—AF occurs in more than half of individuals with HF, and HF occurs in more than one third of individuals with AF. AF precedes and follows HF with both preserved and reduced ejection fraction, with some differences in temporal association and prognosis. Future studies focused on underlying mechanisms of these dual conditions are warranted."
http://circ.ahajournals.org/content/133/5/484.abstract
Wednesday, February 3, 2016
Lancet - "Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: complete follow-up results from the CHAMPION randomised trial"
Lancet - "Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: complete follow-up results from the CHAMPION randomised trial"
"Interpretation
Management of NYHA Class III heart failure based on home transmission of pulmonary artery pressure with an implanted pressure sensor has significant long-term benefit in lowering hospital admission rates for heart failure."
http://lancet.com/pdfs/journals/lancet/PIIS0140-6736(15)00723-0.pdf
Tuesday, February 2, 2016
NEJM - "National Cluster-Randomized Trial of Duty-Hour Flexibility in Surgical Training"
NEJM - "National Cluster-Randomized Trial of Duty-Hour Flexibility in Surgical Training"
"CONCLUSIONS
As compared with standard duty-hour policies, flexible, less-restrictive duty-hour policies for surgical residents were associated with noninferior patient outcomes and no significant difference in residents’ satisfaction with overall well-being and education quality. (FIRST ClinicalTrials.gov number, NCT02050789.)"
http://www.nejm.org/doi/full/10.1056/NEJMoa1515724?query=featured_home
Monday, February 1, 2016
JAMA "Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents"
"Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents"
"CONCLUSIONS
http://www.nejm.org/doi/full/10.1056/NEJMoa1506699?query=featured_home
"CONCLUSIONS
In this multicenter, prospective study of bariatric surgery in adolescents, we found significant improvements in weight, cardiometabolic health, and weight-related quality of life at 3 years after the procedure. Risks associated with surgery included specific micronutrient deficiencies and the need for additional abdominal procedures. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; Teen-LABS ClinicalTrials.gov number, NCT00474318.)"
http://www.nejm.org/doi/full/10.1056/NEJMoa1506699?query=featured_home
Friday, January 29, 2016
Weekly Guideline "AHA/ACC Scientific Statement Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 4: Congenital Heart Disease"
"AHA/ACC Scientific Statement
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 4: Congenital Heart Disease"
http://circ.ahajournals.org/content/132/22/e281.full
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 4: Congenital Heart Disease"
http://circ.ahajournals.org/content/132/22/e281.full
Thursday, January 28, 2016
CIRC - "Physical Activity and Risk of Coronary Heart Disease and Stroke in Older Adults The Cardiovascular Health Study"
"Physical Activity and Risk of Coronary Heart Disease and Stroke in Older Adults The Cardiovascular Health Study"
"Conclusions—These data provide empirical evidence supporting PA recommendations, in particular, walking, to reduce the incidence of CVD among older adults."
http://circ.ahajournals.org/content/133/2/147.abstract
"Conclusions—These data provide empirical evidence supporting PA recommendations, in particular, walking, to reduce the incidence of CVD among older adults."
http://circ.ahajournals.org/content/133/2/147.abstract
Wednesday, January 27, 2016
Lancet - "Continued versus discontinued cannabis use in patients with psychosis: a systematic review and meta-analysis"
"Continued versus discontinued cannabis use in patients with psychosis: a systematic review and meta-analysis"
"Interpretation
http://lancet.com/journals/lanpsy/article/PIIS2215-0366(15)00363-6/abstract
"Interpretation
Continued cannabis use after onset of psychosis predicts adverse outcome, including higher relapse rates, longer hospital admissions, and more severe positive symptoms than for individuals who discontinue cannabis use and those who are non-users. These findings point to reductions in cannabis use as a crucial interventional target to improve outcome in patients with psychosis."
http://lancet.com/journals/lanpsy/article/PIIS2215-0366(15)00363-6/abstract
Tuesday, January 26, 2016
NEJM - "A Randomized Trial of Low-Cost Mesh in Groin Hernia Repair"
"A Randomized Trial of Low-Cost Mesh in Groin Hernia Repair"
"CONCLUSIONS
http://www.nejm.org/doi/full/10.1056/NEJMoa1505126?query=featured_home
"CONCLUSIONS
Rates of hernia recurrence and postoperative complications did not differ significantly between men undergoing hernia repair with low-cost mesh and those undergoing hernia repair with commercial mesh. (Funded by the Swedish Research Council and others; Current Controlled Trials number, ISRCTN20596933.)"
http://www.nejm.org/doi/full/10.1056/NEJMoa1505126?query=featured_home
Monday, January 25, 2016
JAMA - "Association Between Use of Oral Fluconazole During Pregnancy and Risk of Spontaneous Abortion and Stillbirth"
"Association Between Use of Oral Fluconazole During Pregnancy and Risk of Spontaneous Abortion and Stillbirth"
"Conclusions and Relevance In this nationwide cohort study in Denmark, use of oral fluconazole in pregnancy was associated with a statistically significant increased risk of spontaneous abortion compared with risk among unexposed women and women with topical azole exposure in pregnancy. Until more data on the association are available, cautious prescribing of fluconazole in pregnancy may be advisable. Although the risk of stillbirth was not significantly increased, this outcome should be investigated further."
http://jama.jamanetwork.com/article.aspx?articleid=2480487
"Conclusions and Relevance In this nationwide cohort study in Denmark, use of oral fluconazole in pregnancy was associated with a statistically significant increased risk of spontaneous abortion compared with risk among unexposed women and women with topical azole exposure in pregnancy. Until more data on the association are available, cautious prescribing of fluconazole in pregnancy may be advisable. Although the risk of stillbirth was not significantly increased, this outcome should be investigated further."
http://jama.jamanetwork.com/article.aspx?articleid=2480487
Friday, January 22, 2016
Weekly Guideline "AHA/ACC Scientific Statement Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 3: Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy and Other Cardiomyopathies, and Myocarditis"
"AHA/ACC Scientific Statement
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 3: Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy and Other Cardiomyopathies, and Myocarditis"
http://circ.ahajournals.org/content/132/22/e273.full
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 3: Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy and Other Cardiomyopathies, and Myocarditis"
http://circ.ahajournals.org/content/132/22/e273.full
Thursday, January 21, 2016
CIRC - (REVIEW) "Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity A Comprehensive Review"
"Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity
A Comprehensive Review"
"Abstract
Suboptimal nutrition is a leading cause of poor health. Nutrition and policy science have advanced rapidly, creating confusion yet also providing powerful opportunities to reduce the adverse health and economic impacts of poor diets. This review considers the history, new evidence, controversies, and corresponding lessons for modern dietary and policy priorities for cardiovascular diseases, obesity, and diabetes mellitus. Major identified themes include the importance of evaluating the full diversity of diet-related risk pathways, not only blood lipids or obesity; focusing on foods and overall diet patterns, rather than single isolated nutrients; recognizing the complex influences of different foods on long-term weight regulation, rather than simply counting calories; and characterizing and implementing evidence-based strategies, including policy approaches, for lifestyle change. Evidence-informed dietary priorities include increased fruits, nonstarchy vegetables, nuts, legumes, fish, vegetable oils, yogurt, and minimally processed whole grains; and fewer red meats, processed (eg, sodium-preserved) meats, and foods rich in refined grains, starch, added sugars, salt, and trans fat. More investigation is needed on the cardiometabolic effects of phenolics, dairy fat, probiotics, fermentation, coffee, tea, cocoa, eggs, specific vegetable and tropical oils, vitamin D, individual fatty acids, and diet-microbiome interactions. Little evidence to date supports the cardiometabolic relevance of other popular priorities: eg, local, organic, grass-fed, farmed/wild, or non–genetically modified. Evidence-based personalized nutrition appears to depend more on nongenetic characteristics (eg, physical activity, abdominal adiposity, gender, socioeconomic status, culture) than genetic factors. Food choices must be strongly supported by clinical behavior change efforts, health systems reforms, novel technologies, and robust policy strategies targeting economic incentives, schools and workplaces, neighborhood environments, and the food system. Scientific advances provide crucial new insights on optimal targets and best practices to reduce the burdens of diet-related cardiometabolic diseases."
http://circ.ahajournals.org/content/133/2/187.full
A Comprehensive Review"
"Abstract
Suboptimal nutrition is a leading cause of poor health. Nutrition and policy science have advanced rapidly, creating confusion yet also providing powerful opportunities to reduce the adverse health and economic impacts of poor diets. This review considers the history, new evidence, controversies, and corresponding lessons for modern dietary and policy priorities for cardiovascular diseases, obesity, and diabetes mellitus. Major identified themes include the importance of evaluating the full diversity of diet-related risk pathways, not only blood lipids or obesity; focusing on foods and overall diet patterns, rather than single isolated nutrients; recognizing the complex influences of different foods on long-term weight regulation, rather than simply counting calories; and characterizing and implementing evidence-based strategies, including policy approaches, for lifestyle change. Evidence-informed dietary priorities include increased fruits, nonstarchy vegetables, nuts, legumes, fish, vegetable oils, yogurt, and minimally processed whole grains; and fewer red meats, processed (eg, sodium-preserved) meats, and foods rich in refined grains, starch, added sugars, salt, and trans fat. More investigation is needed on the cardiometabolic effects of phenolics, dairy fat, probiotics, fermentation, coffee, tea, cocoa, eggs, specific vegetable and tropical oils, vitamin D, individual fatty acids, and diet-microbiome interactions. Little evidence to date supports the cardiometabolic relevance of other popular priorities: eg, local, organic, grass-fed, farmed/wild, or non–genetically modified. Evidence-based personalized nutrition appears to depend more on nongenetic characteristics (eg, physical activity, abdominal adiposity, gender, socioeconomic status, culture) than genetic factors. Food choices must be strongly supported by clinical behavior change efforts, health systems reforms, novel technologies, and robust policy strategies targeting economic incentives, schools and workplaces, neighborhood environments, and the food system. Scientific advances provide crucial new insights on optimal targets and best practices to reduce the burdens of diet-related cardiometabolic diseases."
http://circ.ahajournals.org/content/133/2/187.full
Wednesday, January 20, 2016
BMJ - "Pre-pregnancy potato consumption and risk of gestational diabetes mellitus: prospective cohort study"
BMJ -
"Pre-pregnancy potato consumption and risk of gestational diabetes mellitus: prospective cohort study"
"What this paper adds Higher levels of potato consumption before pregnancy are associated with greater risk of GDM, and substitution of potatoes with other vegetables, legumes, or whole grain foods might lower the risk."
http://www.bmj.com/content/352/bmj.h6898
"Pre-pregnancy potato consumption and risk of gestational diabetes mellitus: prospective cohort study"
"What this paper adds Higher levels of potato consumption before pregnancy are associated with greater risk of GDM, and substitution of potatoes with other vegetables, legumes, or whole grain foods might lower the risk."
http://www.bmj.com/content/352/bmj.h6898
Tuesday, January 19, 2016
NEJM - (REVIEW) "Relationship between Nonmedical Prescription-Opioid Use and Heroin Use"
REVIEW: "Relationship between Nonmedical Prescription-Opioid Use and Heroin Use"
"The nonmedical use of prescription opioids is a major public health issue in the United States, both because of the overall high prevalence and because of marked increases in associated morbidity and mortality.1 In 2014, a total of 10.3 million persons reported using prescription opioids nonmedically (i.e., using medications that were not prescribed for them or were taken only for the experience or feeling that they caused).2 Emergency department visits involving misuse or abuse of prescription opioids increased 153% between 2004 and 2011, and admissions to substance-abuse treatment programs linked to prescription opioids more than quadrupled between 2002 and 2012.3,4Most troubling, between 2000 and 2014 the rates of death from prescription-opioid overdose nearly quadrupled (from 1.5 to 5.9 deaths per 100,000 persons) (Figure 1)."
http://www.nejm.org/doi/full/10.1056/NEJMra1508490?query=featured_home
"The nonmedical use of prescription opioids is a major public health issue in the United States, both because of the overall high prevalence and because of marked increases in associated morbidity and mortality.1 In 2014, a total of 10.3 million persons reported using prescription opioids nonmedically (i.e., using medications that were not prescribed for them or were taken only for the experience or feeling that they caused).2 Emergency department visits involving misuse or abuse of prescription opioids increased 153% between 2004 and 2011, and admissions to substance-abuse treatment programs linked to prescription opioids more than quadrupled between 2002 and 2012.3,4Most troubling, between 2000 and 2014 the rates of death from prescription-opioid overdose nearly quadrupled (from 1.5 to 5.9 deaths per 100,000 persons) (Figure 1)."
http://www.nejm.org/doi/full/10.1056/NEJMra1508490?query=featured_home
Monday, January 18, 2016
JAMA "Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection"
"Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection"
"Conclusions and Relevance Among adults with recurrent or refractory CDI, the use of frozen compared with fresh FMT did not result in worse proportion of clinical resolution of diarrhea. Given the potential advantages of providing frozen FMT, its use is a reasonable option in this setting."
http://jama.jamanetwork.com/article.aspx?articleid=2481003
"Conclusions and Relevance Among adults with recurrent or refractory CDI, the use of frozen compared with fresh FMT did not result in worse proportion of clinical resolution of diarrhea. Given the potential advantages of providing frozen FMT, its use is a reasonable option in this setting."
http://jama.jamanetwork.com/article.aspx?articleid=2481003
Friday, January 15, 2016
Weekly Guideline "AHA/ACC Scientific Statement Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 2: Preparticipation Screening for Cardiovascular Disease in Competitive Athletes"
Weekly Guideline
"AHA/ACC Scientific Statement Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 2: Preparticipation Screening for Cardiovascular Disease in Competitive Athletes"
http://circ.ahajournals.org/content/132/22/e267.full
"AHA/ACC Scientific Statement Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 2: Preparticipation Screening for Cardiovascular Disease in Competitive Athletes"
http://circ.ahajournals.org/content/132/22/e267.full
Thursday, January 14, 2016
JACC "Coronary CT Angiography for Suspected ACS in the Era of High-Sensitivity Troponins"
JACC
"Coronary CT Angiography for Suspected ACS in the Era of High-Sensitivity Troponins"
"Conclusions
CCTA, applied early in the work-up of suspected ACS, is safe and associated with less outpatient testing and lower costs. However, in the era of hs-troponins, CCTA does not identify more patients with significant CAD requiring coronary revascularization, shorten hospital stay, or allow for more direct discharge from the ED. (Better Evaluation of Acute Chest Pain with Computed Tomography Angiography [BEACON]; NCT01413282)"
http://content.onlinejacc.org/article.aspx?articleID=2479881
"Coronary CT Angiography for Suspected ACS in the Era of High-Sensitivity Troponins"
"Conclusions
CCTA, applied early in the work-up of suspected ACS, is safe and associated with less outpatient testing and lower costs. However, in the era of hs-troponins, CCTA does not identify more patients with significant CAD requiring coronary revascularization, shorten hospital stay, or allow for more direct discharge from the ED. (Better Evaluation of Acute Chest Pain with Computed Tomography Angiography [BEACON]; NCT01413282)"
http://content.onlinejacc.org/article.aspx?articleID=2479881
Wednesday, January 13, 2016
Lancet "Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial"
Lancet
"Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial"
"Interpretation
http://lancet.com/journals/laneur/article/PIIS1474-4422(15)00379-8/abstract
"Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial"
"Interpretation
Our findings suggest that cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with highly treatment-resistant epilepsy. Randomised controlled trials are warranted to characterise the safety profile and true efficacy of this compound."
http://lancet.com/journals/laneur/article/PIIS1474-4422(15)00379-8/abstract
Tuesday, January 12, 2016
NEJM "A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds"
NEJM
"A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds"
"CONCLUSIONS
http://www.nejm.org/doi/full/10.1056/NEJMoa1508502?query=featured_home
"A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds"
"CONCLUSIONS
The rates of reoperation were similar regardless of irrigation pressure, a finding that indicates that very low pressure is an acceptable, low-cost alternative for the irrigation of open fractures. The reoperation rate was higher in the soap group than in the saline group. (Funded by the Canadian Institutes of Health Research and others; FLOW ClinicalTrials.gov number, NCT00788398.)"
http://www.nejm.org/doi/full/10.1056/NEJMoa1508502?query=featured_home
Monday, January 11, 2016
JAMA - "Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction"
JAMA
"Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction"
"Conclusions and Relevance Among obese older patients with clinically stable HFPEF, caloric restriction or aerobic exercise training increased peak V̇o2, and the effects may be additive. Neither intervention had a significant effect on quality of life as measured by the MLHF Questionnaire."
http://jama.jamanetwork.com/article.aspx?articleid=2480484
"Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction"
"Conclusions and Relevance Among obese older patients with clinically stable HFPEF, caloric restriction or aerobic exercise training increased peak V̇o2, and the effects may be additive. Neither intervention had a significant effect on quality of life as measured by the MLHF Questionnaire."
http://jama.jamanetwork.com/article.aspx?articleid=2480484
Friday, January 8, 2016
Weekly Guideline - "AHA/ACC Scientific Statement Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 1: Classification of Sports: Dynamic, Static, and Impact"
"AHA/ACC Scientific Statement
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 1: Classification of Sports: Dynamic, Static, and Impact"
http://circ.ahajournals.org/content/132/22/e262
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities:
Task Force 1: Classification of Sports: Dynamic, Static, and Impact"
http://circ.ahajournals.org/content/132/22/e262
Thursday, January 7, 2016
CIRC - "Hypertrophic Cardiomyopathy in Children, Adolescents, and Young Adults Associated With Low Cardiovascular Mortality With Contemporary Management Strategies"
"Hypertrophic Cardiomyopathy in Children, Adolescents, and Young Adults Associated With Low Cardiovascular Mortality With Contemporary Management Strategies"
"Conclusions—In a large hospital-based cohort of young HCM patients, representing an age group considered at greatest risk, low mortality rates can be achieved with the application of contemporary cardiovascular treatment strategies, largely because of reliable identification of high-risk patients who benefited from implantable cardioverter-defibrillators for sudden death prevention, thereby creating the opportunity for extended longevity and good quality of life."
http://circ.ahajournals.org/content/133/1/62.abstract
"Conclusions—In a large hospital-based cohort of young HCM patients, representing an age group considered at greatest risk, low mortality rates can be achieved with the application of contemporary cardiovascular treatment strategies, largely because of reliable identification of high-risk patients who benefited from implantable cardioverter-defibrillators for sudden death prevention, thereby creating the opportunity for extended longevity and good quality of life."
http://circ.ahajournals.org/content/133/1/62.abstract
Wednesday, January 6, 2016
BMJ - "Nosocomial transmission of avian influenza A (H7N9) virus in China: epidemiological investigation"
"Nosocomial transmission of avian influenza A (H7N9) virus in China: epidemiological investigation"
"What this study adds
Nosocomial H7N9 transmission might be possible between two unrelated individuals. Surveillance on patients with influenza-like illness in hospitals as well as chickens in live poultry markets should be enhanced to monitor transmissibility and pathogenicity of the virus."
"What this study adds
Nosocomial H7N9 transmission might be possible between two unrelated individuals. Surveillance on patients with influenza-like illness in hospitals as well as chickens in live poultry markets should be enhanced to monitor transmissibility and pathogenicity of the virus."
Tuesday, January 5, 2016
NEJM - "Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection"
"Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection"
"CONCLUSIONS
http://www.nejm.org/doi/full/10.1056/NEJMoa1512610?query=featured_home
"CONCLUSIONS
Once-daily sofosbuvir–velpatasvir for 12 weeks provided high rates of sustained virologic response among both previously treated and untreated patients infected with HCV genotype 1, 2, 4, 5, or 6, including those with compensated cirrhosis. (Funded by Gilead Sciences; ClinicalTrials.gov number, NCT02201940.)"
http://www.nejm.org/doi/full/10.1056/NEJMoa1512610?query=featured_home
Monday, January 4, 2016
JAMA - "Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease"
"Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease"
"Conclusions and Relevance Among adult patients with refractory Crohn disease not amenable to surgery who had impaired quality of life, HSCT, compared with conventional therapy, did not result in a statistically significant improvement in sustained disease remission at 1 year and was associated with significant toxicity. These findings do not support the widespread use of HSCT for patients with refractory Crohn disease."
http://jama.jamanetwork.com/article.aspx?articleid=2475462
"Conclusions and Relevance Among adult patients with refractory Crohn disease not amenable to surgery who had impaired quality of life, HSCT, compared with conventional therapy, did not result in a statistically significant improvement in sustained disease remission at 1 year and was associated with significant toxicity. These findings do not support the widespread use of HSCT for patients with refractory Crohn disease."
http://jama.jamanetwork.com/article.aspx?articleid=2475462
Friday, January 1, 2016
Weekly Guideline - "AHA Scientific Statement The Agenda for Familial Hypercholesterolemia"
"AHA Scientific Statement
The Agenda for Familial Hypercholesterolemia"
http://circ.ahajournals.org/content/132/22/2167
The Agenda for Familial Hypercholesterolemia"
http://circ.ahajournals.org/content/132/22/2167
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