Thursday, February 28, 2013

"Long term calcium intake and rates of all cause and cardiovascular mortality: community based prospective longitudinal cohort study"  
BMJ Feb 13
http://www.bmj.com/content/346/bmj.f228
"Conclusion High intakes of calcium in women are associated with higher death rates from all causes and cardiovascular disease but not from stroke."

Wednesday, February 27, 2013

"Primary Prevention of Cardiovascular Disease with a Mediterranean Diet"
NEJM Feb 25
http://www.nejm.org/doi/full/10.1056/NEJMoa1200303?query=featured_home
"CONCLUSIONS

Among persons at high cardiovascular risk, a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced the incidence of major cardiovascular events. (Funded by the Spanish government's Instituto de Salud Carlos III and others; Controlled-Trials.com number,ISRCTN35739639.)"

"A Comparison of the Cell Phone Driver and the Drunk Driver"
Distraction.gov
http://www.distraction.gov/download/research-pdf/Comparison-of-CellPhone-Driver-Drunk-Driver.pdf

Tuesday, February 26, 2013

"Association of Hydroxyethyl Starch Administration With Mortality and Acute Kidney Injury in Critically Ill Patients Requiring Volume Resuscitation"  

JAMA Feb 20
http://jama.jamanetwork.com/article.aspx?articleid=1653505
"
Conclusion and Relevance  In critically ill patients requiring acute volume resuscitation, use of hydroxyethyl starch compared with other resuscitation solutions was not associated with a decrease in mortality. Moreover, after exclusion of 7 trials performed by an investigator whose research has been retracted because of scientific misconduct, hydroxyethyl starch was associated with a significant increased risk of mortality and acute kidney injury. Clinical use of hydroxyethyl starch for acute volume resuscitation is not warranted due to serious safety concerns."

Friday, February 22, 2013


"Prehypertension and Hypertension in Community-Based Pediatric Practice"
Pediatrics Jan 28
http://pediatrics.aappublications.org/content/131/2/e415.abstract
"CONCLUSIONS: The prevalence of hypertension in this community-based study is lower than previously reported from school-based studies. With the size and diversity of this cohort, these results suggest the prevalence of hypertension in children may actually be lower than previously reported."

Thursday, February 21, 2013

"Percutaneous Coronary Intervention Versus Coronary Bypass Surgery in United States Veterans With Diabetes"  
JACC Feb 2013
http://content.onlinejacc.org/article.aspx?articleid=1653065

Wednesday, February 20, 2013

"Imatinib Mesylate as Add-On Therapy for Pulmonary Arterial Hypertension: Results of the Randomized IMPRES Study"
Circ Feb 12, 2013
http://circ.ahajournals.org/content/early/2013/02/12/CIRCULATIONAHA.112.000765.abstract
"Conclusions—Imatinib improved exercise capacity and hemodynamics in patients with advanced PAH but serious adverse events and study drug discontinuations were common. Further studies are needed to investigate the long-term safety and efficacy of imatinib in patients with PAH."

Tuesday, February 19, 2013

"Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial"
Lancet Feb 14 (online)
http://www.lancet.com/journals/lancet/article/PIIS0140-6736(12)62186-2/abstract
"Findings

1610 patients were randomly assigned to receive either colonoscopy (n=1072) or CTC (n=538). 30 patients withdrew consent, leaving for analysis 1047 assigned to colonoscopy and 533 assigned to CTC. 160 (30·0%) patients in the CTC group had additional colonic investigation compared with 86 (8·2%) in the colonoscopy group (relative risk 3·65, 95% CI 2·87—4·65; p<0·0001). Almost half the referrals after CTC were for small (<10 mm) polyps or clinical uncertainty, with low predictive value for large polyps or cancer. Detection rates of colorectal cancer or large polyps in the trial cohort were 11% for both procedures. CTC missed 1 of 29 colorectal cancers and colonoscopy missed none (of 55). Serious adverse events were rare.

Interpretation

Guidelines are needed to reduce the referral rate after CTC. For most patients, however, CTC provides a similarly sensitive, less invasive alternative to colonoscopy."

Monday, February 18, 2013

"Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis"
BMJ Feb 2013
http://www.bmj.com/content/346/bmj.f839
"Conclusion
In conventional meta-analyses including recent trial data, hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin increased the use of renal replacement therapy and transfusion with red blood cells, and resulted in more serious adverse events in patients with sepsis. It seems unlikely that hydroxyethyl starch 130/0.38-0.45 provides overall clinical benefit for patients with sepsis."
"Neurostimulation for Parkinson's Disease with Early Motor Complications"
NEJM Feb 14 2103

http://www.nejm.org/doi/full/10.1056/NEJMoa1205158


"
Association Between Maternal Use of Folic Acid Supplements and Risk of Autism Spectrum Disorders in Children"

JAMA Feb 13 2013
http://jama.jamanetwork.com/article.aspx?articleid=1570279

Saturday, February 16, 2013

"Dextrose Saline Compared With Normal Saline Rehydration of Hyperemesis Gravidarum: A Randomized Controlled Trial"OB & Gyn Feb 2013
http://journals.lww.com/greenjournal/Fulltext/2013/02000/Dextrose_Saline_Compared_With_Normal_Saline.13.aspx

"Physical Activity and 3-Year BMI Change in Overweight and Obese Children"
Pediatrics Jan 2013 (online)
http://pediatrics.aappublications.org/content/131/2/e470.abstract

Thursday, February 14, 2013

MMWR:
"Advisory Committee on Immunization Practices (ACIP) Recommended Immunization Schedules for Persons Aged 0 Through 18 years and Adults Aged 19 Years and Older — United States, 2013"

CDC /ACIP

http://www.cdc.gov/mmwr/preview/mmwrhtml/su6201a1.htm?s_cid=su6201a1_w#PlacingSchedulesWebsite

Wednesday, February 13, 2013

"Paclitaxel-eluting balloons, paclitaxel-eluting stents, and balloon angioplasty in patients with restenosis after implantation of a drug-eluting stent (ISAR-DESIRE 3): a randomised, open-label trial"
Lancet Feb 9
http://www.lancet.com/journals/lancet/article/PIIS0140-6736(12)61964-3/fulltext
"Interpretation

By obviating the need for additional stent implantation, PEB could be a useful treatment for patients with restenosis after implantation of a drug-eluting stent."


"
Use of dietary linoleic acid for secondary prevention of coronary heart disease and death"
BMJ Feb 5http://www.bmj.com/content/346/bmj.e8707
"Conclusions Advice to substitute polyunsaturated fats for saturated fats is a key component of worldwide dietary guidelines for coronary heart disease risk reduction. However, clinical benefits of the most abundant polyunsaturated fatty acid, omega 6 linoleic acid, have not been established. In this cohort, substituting dietary linoleic acid in place of saturated fats increased the rates of death from all causes, coronary heart disease, and cardiovascular disease. An updated meta-analysis of linoleic acid intervention trials showed no evidence of cardiovascular benefit. These findings could have important implications for worldwide dietary advice to substitute omega 6 linoleic acid, or polyunsaturated fats in general, for saturated fats."

Tuesday, February 12, 2013

"Effect of Ramipril on Walking Times and Quality of Life Among Patients With Peripheral Artery Disease and Intermittent Claudication"
JAMA Feb 6
http://jama.jamanetwork.com/article.aspx?articleid=1568251

"Rivaroxaban for Thromboprophylaxis in Acutely Ill Medical Patients"
NEJM Feb 7
http://www.nejm.org/doi/full/10.1056/NEJMoa1111096"CONCLUSIONS

In acutely ill medical patients, rivaroxaban was noninferior to enoxaparin for standard-duration thromboprophylaxis. Extended-duration rivaroxaban reduced the risk of venous thromboembolism. Rivaroxaban was associated with an increased risk of bleeding. (Funded by Bayer HealthCare Pharmaceuticals and Janssen Research and Development; MAGELLAN ClinicalTrials.gov number,NCT00571649.)"

"Effect of Ramipril on Walking Times and Quality of Life Among Patients With Peripheral Artery Disease and Intermittent Claudication"
JAMA Feb 6
http://jama.jamanetwork.com/article.aspx?articleid=1568251
"Conclusions and Relevance
 Among patients with intermittent claudication, 24-week treatment with ramipril resulted in significant increases in pain-free and maximum treadmill walking times compared with placebo. This was associated with a significant increase in the physical functioning component of the SF-36 score."

Sunday, February 10, 2013

"Prognosis Among Healthy Individuals Discharged With a Primary Diagnosis of Syncope"  
JACC Jan 2013 
http://content.onlinejacc.org/article.aspx?articleid=1484452
"Conclusions  The first admission for syncope among healthy individuals significantly predicts the risk of all-cause mortality, stroke, cardiovascular hospitalization, device implantation, and recurrent syncope."

"Risk Stratification and Outcome of Patients With Hypertrophic Cardiomyopathy ≥60 Years of Age"  
Circ Feb 5 
http://circ.ahajournals.org/content/127/5/585.abstract

Friday, February 8, 2013

"Stratifying Risk of Urinary Tract Malignant Tumors in Patients With Asymptomatic Microscopic Hematuria"
Mayo Clin proc Jam 2013
http://www.mayoclinicproceedings.org/article/S0025-6196(12)00990-1/fulltext

"Cardiac tamponade: 12 pearls in diagnosis and management"
CCJM Feb 2013
http://ccjm.org/content/80/2/109.full
"Key points
Slow accumulation of pericardial fluid can result in edema, whereas rapid accumulation leads to hypotension.
Diuretics can worsen tamponade by removing enough volume from the circulation to lower the central venous pressure below the intrapericardial pressure.
Try to determine why cardiac tamponade has occurred. Cardiac or aortic rupture requires surgery. If the gross appearance of the pericardial fluid does not match the presumed etiology, reconsider your diagnosis. . . . "

Thursday, February 7, 2013

"Endovascular Treatment for Acute Ischemic Stroke"
NEJM Feb 6
http://www.nejm.org/doi/full/10.1056/NEJMoa1213701?query=featured_home
"The results of this trial in patients with acute ischemic stroke indicate that endovascular therapy is not superior to standard treatment with intravenous t-PA.
(Funded by the Italian Medicines Agency, ClinicalTrials.gov number, 
NCT00640367.)"

"Effect of Corticosteroid Injection, Physiotherapy, or Both on Clinical Outcomes in Patients With Unilateral Lateral Epicondylalgia"  
JAMA Feb 6
http://jama.jamanetwork.com/article.aspx?articleid=1568252
"
Conclusion and Relevance 
Among patients with chronic unilateral lateral epicondylalgia, the use of corticosteroid injection vs placebo injection resulted in worse clinical outcomes after 1 year, and physiotherapy did not result in any significant differences."

Wednesday, February 6, 2013

"Dietary and Supplemental Calcium Intake and Cardiovascular Disease Mortality" JAMA Intern Med Feb 2013
http://archinte.jamanetwork.com/article.aspx?articleid=1568523
"Conclusions and Relevance 
Our findings suggest that high intake of supplemental calcium is associated with an excess risk of CVD death in men but not in women. Additional studies are needed to investigate the effect of supplemental calcium use beyond bone health."


"Comparative Effectiveness of Alternative Prostate-Specific Antigen–Based Prostate Cancer Screening Strategies"
Ann Intern Med Feb 2013
http://annals.org/article.aspx?articleid=1567368
"Conclusion: Compared with standard screening, PSA screening strategies that use higher thresholds for biopsy referral for older men and that screen men with low PSA levels less frequently can reduce harms while preserving lives."

Monday, February 4, 2013

"Bupropion for Smoking Cessation in Patients Hospitalized With Acute Myocardial Infarction"
JACC Feb 2013
http://content.onlinejacc.org/article.aspx?articleid=1559966
"
Conclusions  Two-thirds of patients return to smoking by 12 months after AMI. Bupropion is well tolerated and seems to be safe to use in the immediate post-AMI period. However, bupropion is not effective for smoking cessation in patients post-AMI. (Zyban as an Effective Smoking Cessation Aid for Patients Following an Acute Coronary Syndrome: The ZESCA Trial; NCT00689611)"

"Prospective studies of total and ionized serum calcium in relation to incident and fatal ovarian cancer"

Gyn Onc Jan 2013
http://www.sciencedirect.com/science/article/pii/S009082581300005X

Sunday, February 3, 2013

"Chest Compression Alone Cardiopulmonary Resuscitation Is Associated With Better Long-Term Survival Compared with Standard Cardiopulmonary Resuscitation"
Circulation Jan 29
http://circ.ahajournals.org/content/127/4/435.full



GUIDELINE:
"AHA/ASA Guideline 

Guidelines for the Early Management of Patients With Acute Ischemic Stroke"

Stroke Feb 2013
http://stroke.ahajournals.org/content/early/2013/01/31/STR.0b013e318284056a.full

Friday, February 1, 2013

"The Association of Aspirin Use With Age-Related Macular Degeneration"
JAMA IM Jan 21
http://archinte.jamanetwork.com/article.aspx?articleid=1558450
"
Conclusion  Regular aspirin use is associated with increased risk of incident neovascular AMD, independent of a history of cardiovascular disease and smoking."

"
Screening for Intimate Partner Violence and Abuse of Elderly and Vulnerable Adults: A U.S. Preventive Services Task Force Recommendation Statement"
Ann Intern Med Jan 22
http://annals.org/article.aspx?articleid=1558517
"
The U.S. Preventive Services Task Force (USPSTF) recommends that clinicians screen women of childbearing age for intimate partner violence (IPV), such as domestic violence, and provide or refer women who screen positive to intervention services (B recommendation). This recommendation applies to women who do not have signs or symptoms of abuse. See the Clinical Considerations for more information on effective interventions."
"Abluminal biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent (COMPARE II): a randomised, controlled, non-inferiority trial"
Lancet Jan 30
http://www.lancet.com/journals/lancet/article/PIIS0140-6736(12)61852-2/abstract
"Interpretation
Biodegradable polymer biolimus-eluting stents are as safe and efficacious as the current standard of a thin-strut everolimus-eluting stent with a durable biocompatible polymer. We need to follow-up patients for longer to show whether the biolimus-eluting stent reduces the risk of stent thrombosis after 1 year when compared with the everolimus-eluting stent."