"Vaccine for Prevention of Mild and Moderate-to-Severe Influenza in Children"
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1215817?query=featured_home 
"CONCLUSIONS

The QIV was efficacious in preventing influenza in children. (Funded by GlaxoSmithKline Biologicals; ClinicalTrials.gov number,NCT01218308.)"

"Prolonged Exposure vs Supportive Counseling for Sexual Abuse–Related PTSD in Adolescent Girls"
JAMA
http://jama.jamanetwork.com/article.aspx?articleid=1793800 
"Conclusion and Relevance  Adolescents girls with sexual abuse–related PTSD experienced greater benefit from prolonged exposure therapy than from supportive counseling even when delivered by counselors who typically provide supportive counseling."

Weekly Guideline

"Treatment of Anemia in Patients With Heart Disease: A Clinical Practice Guideline From the American College of Physicians"
Annals
http://annals.org/article.aspx?articleid=1784292
"Recommendation 1: ACP recommends using a restrictive red blood cell transfusion strategy (trigger hemoglobin threshold of 7 to 8 g/dL compared with higher hemoglobin levels) in hospitalized patients with coronary heart disease. (Grade: weak recommendation; low-quality evidence)

Recommendation 2: ACP recommends against the use of erythropoiesis-stimulating agents in patients with mild to moderate anemia and congestive heart failure or coronary heart disease. (Grade: strong recommendation; moderate-quality evidence)"

"Renoprotective Effect of Renin-Angiotensin-Aldosterone System Blockade in Patients With Predialysis Advanced Chronic Kidney Disease, Hypertension, and Anemia"

"Renoprotective Effect of Renin-Angiotensin-Aldosterone System Blockade in Patients With Predialysis Advanced Chronic Kidney Disease, Hypertension, and Anemia"
JAMA IM
http://archinte.jamanetwork.com/article.aspx?articleid=1787693
"Conclusions and Relevance  Patients with stable hypertension and advanced CKD who receive therapy with ACEIs/ARBs exhibit an association with lower risk for long-term dialysis or death by 6%. This benefit does not increase the risk of all-cause mortality."

"Discordance of LDL Cholesterol with Alternative LDL-Related Measures and Future Coronary Events"
Circ
http://circ.ahajournals.org/content/early/2013/12/17/CIRCULATIONAHA.113.005873.abstract
"Conclusions—For women with discordant LDL-related measures, coronary risk may be under or overestimated when relying on LDL-C alone."

"Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis"
BMJ
http://www.bmj.com/content/347/bmj.f6879 
"Conclusions Greater dietary fibre intake is associated with a lower risk of both cardiovascular disease and coronary heart disease. Findings are aligned with general recommendations to increase fibre intake. The differing strengths of association by fibre type or source highlight the need for a better understanding of the mode of action of fibre components."

"Use of Selective Serotonin Reuptake Inhibitors during Pregnancy and Risk of Autism"  
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1301449
"CONCLUSIONS

We did not detect a significant association between maternal use of SSRIs during pregnancy and autism spectrum disorder in the offspring. On the basis of the upper boundary of the confidence interval, our study could not rule out a relative risk up to 1.61, and therefore the association warrants further study."

"Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Renal Dysfunction"  
JAMA
http://jama.jamanetwork.com/article.aspx?articleid=1779722
"Conclusion and Relevance  In participants with acute heart failure and renal dysfunction, neither low-dose dopamine nor low-dose nesiritide enhanced decongestion or improved renal function when added to diuretic therapy."

Weekly Guideline Update: HTN

"2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)"
JAMA
http://jama.jamanetwork.com/article.aspx?articleid=1791497

"Oral High-Dose Multivitamins and Minerals After Myocardial Infarction: A Randomized Trial"
Annals
http://annals.org/article.aspx?articleid=1789248
"Conclusion: High-dose oral multivitamins and multiminerals did not statistically significantly reduce cardiovascular events in patients after MI who received standard medications. However, this conclusion is tempered by the nonadherence rate."  

"Treatment of Acute Venous Thromboembolism with Dabigatran or Warfarin and Pooled Analysis"   
Circ
http://circ.ahajournals.org/content/early/2013/12/10/CIRCULATIONAHA.113.004450.abstract 
"Conclusions—Dabigatran has similar effect on VTE recurrence and a lower risk of bleeding compared to warfarin for the treatment of acute VTE."

"Vitamin D status and ill health: a systematic review"
Lancet
http://www.thelancet.com/journals/landia/article/PIIS2213-8587(13)70165-7/fulltext?_eventId=login 
"Conclusions

Many prospective studies have shown associations between low 25(OH)D concentrations and a wide range of acute and chronic health disorders. However, an equally similar number of randomised trials have not confirmed that raising of 25(OH)D concentrations can modify the occurrence or clinical course of these disorders. Hence, associations between 25(OH)D and health disorders reported by investigators of observational studies are not causal. Low 25(OH)D could be the result of inflammatory processes involved in the occurrence and progression of disease. An exception would be slight gains in survival after the restoration of vitamin D deficits due to lifestyle changes induced by ageing and ill health. Five trials including 2150—20 000 patients aged 50 years or older are in progress, testing whether vitamin D supplementation at 40—80 μg per day can reduce the risk of cancer, cardiovascular diseases, diabetes, infections, declining cognitive functions, and fractures.63 The first results are not expected before 2017, but these studies have the potential to test our hypotheses."

"Bivalirudin Started during Emergency Transport for Primary PCI"
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1311096 
"CONCLUSIONS

Bivalirudin, started during transport for primary PCI, improved 30-day clinical outcomes with a reduction in major bleeding but with an increase in acute stent thrombosis."

"Effect of CPAP on Blood Pressure in Patients With Obstructive Sleep Apnea and Resistant Hypertension The HIPARCO Randomized Clinical Trial'
JAMA
http://jama.jamanetwork.com/article.aspx?articleid=1788459 
"Conclusions and Relevance  Among patients with OSA and resistant hypertension, CPAP treatment for 12 weeks compared with control resulted in a decrease in 24-hour mean and diastolic blood pressure and an improvement in the nocturnal blood pressure pattern. Further research is warranted to assess longer-term health outcomes."

Weekly Guideline

"Lipid Management in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2013 Clinical Practice Guideline"   
http://annals.org/article.aspx?articleid=1788220

"Overdiagnosis in Low-Dose Computed Tomography Screening for Lung Cancer"
JAMA IM
http://archinte.jamanetwork.com/article.aspx?articleid=1785197 
"Conclusions and Relevance  More than 18% of all lung cancers detected by LDCT in the NLST seem to be indolent, and overdiagnosis should be considered when describing the risks of LDCT screening for lung cancer."

"Patient and Hospital Characteristics Associated With Inappropriate Percutaneous Coronary Interventions"
http://content.onlinejacc.org/article.aspx?articleid=1738849   
JACC
"Conclusions  For nonacute indications, PCIs categorized as inappropriate were more commonly performed in men, whites, and those who had private insurance. Higher rates of PCI in these patient populations may, in part, be due to procedural overuse."

"Role of diuretics, β blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study"  
BMJ  
http://www.bmj.com/content/347/bmj.f6745   
"Conclusions Among people with impaired glucose tolerance and other cardiovascular risk factors and with serial glucose measurements, diuretics and statins were associated with an increased risk of new onset diabetes, whereas the effect of β blockers was non-significant."  

"Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest"
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1310519 
"CONCLUSIONS

In unconscious survivors of out-of-hospital cardiac arrest of presumed cardiac cause, hypothermia at a targeted temperature of 33°C did not confer a benefit as compared with a targeted temperature of 36°C."

"Rates of Medical Errors and Preventable Adverse Events Among Hospitalized Children Following Implementation of a Resident Handoff Bundle"
JAMA
http://jama.jamanetwork.com/article.aspx?articleid=1787406 
"Conclusions and Relevance  Implementation of a handoff bundle was associated with a significant reduction in medical errors and preventable adverse events among hospitalized children. Improvements in verbal and written handoff processes occurred, and resident workflow did not change adversely."

Weekly Guideline

"International Expert Consensus Statement
Percutaneous Transluminal Renal Denervation for the Treatment of Resistant Hypertension"
JACC
http://content.onlinejacc.org/article.aspx?articleid=1738851

"Are Metabolically Healthy Overweight and Obesity Benign Conditions?: A Systematic Review and Meta-analysis"
Annals
http://annals.org/article.aspx?articleid=1784291
"Conclusion: Compared with metabolically healthy normal-weight individuals, obese persons are at increased risk for adverse long-term outcomes even in the absence of metabolic abnormalities, suggesting that there is no healthy pattern of increased weight."

"Syncope Without Prodromes in Patients With Normal Heart and Normal Electrocardiogram"
JACC
http://content.onlinejacc.org/article.aspx?articleid=1709459   
"Conclusions  Common clinical features and a low adenosine plasmatic level define a distinct form of syncope, distinguish it from VVS, and suggest a causal role of the adenosine pathway."

"Association between cardiovascular events and sodium-containing effervescent, dispersible, and soluble drugs: nested case-control study"
BMJ
http://www.bmj.com/content/347/bmj.f6954
"Conclusions Exposure to sodium-containing formulations of effervescent, dispersible, and soluble medicines was associated with significantly increased odds of adverse cardiovascular events compared with standard formulations of those same drugs. Sodium-containing formulations should be prescribed with caution only if the perceived benefits outweigh these risks."

"Edoxaban versus Warfarin in Patients with Atrial Fibrillation"
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1310907
"CONCLUSIONS

Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number,NCT00781391.)"

"Induced Hypothermia in Severe Bacterial Meningitis"  JAMA
http://jama.jamanetwork.com/article.aspx?articleid=1748835 
"Conclusions and Relevance  Moderate hypothermia did not improve outcome in patients with severe bacterial meningitis and may even be harmful. Careful evaluation of safety issues in future trials on hypothermia are needed and may have important implications in patients presenting with septic shock or stroke."