"Treatment of Anemia with Darbepoetin Alfa in Systolic Heart Failure"
NEJM Mar 10
http://www.nejm.org/doi/full/10.1056/NEJMoa1214865 
"CONCLUSIONS 

Treatment with darbepoetin alfa did not improve clinical outcomes in patients with systolic heart failure and mild-to-moderate anemia. Our findings do not support the use of darbepoetin alfa in these patients."

"Effect of Disodium EDTA Chelation Regimen on Cardiovascular Events in Patients With Previous Myocardial Infarction 

The TACT Randomized Trial" 

JAMA Mar 27  
http://jama.jamanetwork.com/article.aspx?articleid=1672238 

"Effect of the 2011 vs 2003 Duty Hour Regulation–Compliant Models on Sleep Duration, Trainee Education, and Continuity of Patient Care Among Internal Medicine House Staff"  
JAMA IM Mar 25
http://archinte.jamanetwork.com/article.aspx?articleid=1672279 

"The Top Patient Safety Strategies That Can Be Encouraged for Adoption Now"  
Annals Intern Med Mar 5  
http://annals.org/article.aspx?articleid=1657884  

"Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial" 
Lancet Feb 27
http://www.lancet.com/journals/lancet/article/PIIS0140-6736(13)60141-5/fulltext
"Interpretation

CABG should remain the standard of care for patients with complex lesions (high or intermediate SYNTAX scores). For patients with less complex disease (low SYNTAX scores) or left main coronary disease (low or intermediate SYNTAX scores), PCI is an acceptable alternative. All patients with complex multivessel coronary artery disease should be reviewed and discussed by both a cardiac surgeon and interventional cardiologist to reach consensus on optimum treatment."

"Use of high potency statins and rates of admission for acute kidney injury"
BMJ Mar 19
http://www.bmj.com/content/346/bmj.f880 
"Conclusions Use of high potency statins is associated with an increased rate of diagnosis for acute kidney injury in hospital admissions compared with low potency statins. The effect seems to be strongest in the first 120 days after initiation of statin treatment."

"Percutaneous Closure of Patent Foramen Ovale in Cryptogenic Embolism"
NEJM Mar 21
http://www.nejm.org/doi/full/10.1056/NEJMoa1211716?query=featured_home
"CONCLUSIONS

Closure of a patent foramen ovale for secondary prevention of cryptogenic embolism did not result in a significant reduction in the risk of recurrent embolic events or death as compared with medical therapy. (Funded by St. Jude Medical; ClinicalTrials.gov number,NCT00166257.)"

"Effect of Aliskiren on Postdischarge Mortality and Heart Failure Readmissions Among Patients Hospitalized for Heart Failure

The ASTRONAUT Randomized Trial"

JAMA Mar 20 (online first)
http://jama.jamanetwork.com/article.aspx?articleid=1666394
"Conclusion and Relevance  Among patients hospitalized for HF with reduced LVEF, initiation of aliskiren in addition to standard therapy did not reduce CV death or HF rehospitalization at 6 months or 12 months after discharge."

"Vitamin D and Calcium Supplementation to Prevent Fractures in Adults: U.S. Preventive Services Task Force Recommendation Statement"
Annals Intern Med Feb 26
http://annals.org/article.aspx?articleid=1655858

"Violent offending by UK military personnel deployed to Iraq and Afghanistan: a data linkage cohort study"
Lancet Mar 16
http://www.lancet.com/journals/lancet/article/PIIS0140-6736(13)60354-2/fulltext
"Interpretation

Alcohol misuse and aggressive behaviour might be appropriate targets for interventions, but any action must be evidence based. Post-traumatic stress disorder, though less prevalent, is also a risk factor for violence, especially hyperarousal symptoms, so if diagnosed it should be appropriately treated and associated risk monitored."

"Nonemergency PCI at Hospitals with or without On-Site Cardiac Surgery"  
NEJM Mar 11
http://www.nejm.org/doi/full/10.1056/NEJMoa1300610?query=featured_home
"CONCLUSIONS

Nonemergency PCI procedures performed at hospitals in Massachusetts without on-site surgical services were noninferior to procedures performed at hospitals with on-site surgical services with respect to the 30-day and 1-year rates of clinical events. (Funded by the participating hospitals without on-site cardiac surgery; MASS COM ClinicalTrials.gov number, NCT01116882.)"

"Cognitive function and other risk factors for mild traumatic brain injury in young men: nationwide cohort study"
BMJ Mar 13  
http://www.bmj.com/content/346/bmj.f723

"Prevalence of Regional Myocardial Thinning and Relationship With Myocardial Scarring in Patients With Coronary Artery Disease" 
JAMA Mar 6
http://jama.jamanetwork.com/article.aspx?articleid=1660383

"Randomized controlled trial to prevent postpartum depression in adolescent mothers"
AJOG Mar 2013
http://www.ajog.org/article/S0002-9378(13)00003-3/fulltext 
"Results

Participants included Hispanic (53%), non-Hispanic black (17%), and non-Hispanic white (16%) adolescents. The overall rate of depression in the intervention group (12.5%) was lower than the control group (25%) with a hazard rate ratio of 0.44 (95% confidence interval, 0.17−1.15) at 6 months after delivery.

Conclusion

An intervention that is delivered during the prenatal period has the potential to reduce the risk for postpartum depression in primiparous adolescent mothers."

"Triglyceride to HDL-C Ratio and Increased Arterial Stiffness in Children, Adolescents, and Young Adults"

Pediatrics Mar 2013 

http://pediatrics.aappublications.org/content/early/2013/02/26/peds.2012-1726

"Low Sodium Diets Increase Mortality and Readmission Rate in Patients with Systolic Heart Failure Taking Daily Diuretics"

DynaMed Jan 2013
http://archive.constantcontact.com/fs132/1102736301344/archive/1112308559205.html

"ACCF/HRS/AHA/ASE/HFSA/SCAI/SCCT/SCMR 2013 Appropriate Use Criteria for Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy"
JACC Feb 2013 
http://content.onlinejacc.org/article.aspx?articleID=1659563


"Circulation: Clinical Summaries

Original Research Put Into Perspective for the Practicing Clinician"

Circulation Feb 2013
http://circ.ahajournals.org/content/127/8/863.full

"Palliative use of non-invasive ventilation in end-of-life patients with solid tumours: a randomised feasibility trial"  
Lancet Mar 2013
http://www.lancet.com/journals/lanonc/article/PIIS1470-2045(13)70009-3/fulltext
"Interpretation

Our findings suggest that NIV is more effective compared with oxygen in reducing dyspnoea and decreasing the doses of morphine needed in patients with end-stage cancer. Further studies are needed to confirm our findings and to assess the effectiveness of NIV on other outcomes such as survival. The use of NIV is, however, restricted to centres with NIV equipment, our findings are not generalisable to all cancer or palliative care units."