JAMA - "Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis"

"Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis"

"Conclusions and Relevance  Among patients with CT-proven, uncomplicated appendicitis, antibiotic treatment did not meet the prespecified criterion for noninferiority compared with appendectomy. Most patients randomized to antibiotic treatment for uncomplicated appendicitis did not require appendectomy during the 1-year follow-up period, and those who required appendectomy did not experience significant complications."

http://jama.jamanetwork.com/article.aspx?articleid=2320315

Weekly Guideline - 2012 IDSA "Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of America"

http://cid.oxfordjournals.org/content/early/2012/11/29/cid.cis803.abstract.html?papetoc

CIRC - Oxygen in STEMI

"Air Versus Oxygen in ST-Segment–Elevation Myocardial Infarction"

"Conclusion—Supplemental oxygen therapy in patients with ST-elevation–myocardial infarction but without hypoxia may increase early myocardial injury and was associated with larger myocardial infarct size assessed at 6 months."

http://circ.ahajournals.org/content/131/24/2143.abstract

BMJ - Perioperative Transfusion

"Harms associated with single unit perioperative transfusion: retrospective population based analysis"

"Conclusions
A perioperative transfusion of one unit of packed red blood cells is associated with increased odds of perioperative ischemic stroke and/or myocardial infarction, even after adjustment for a wide range of factors in our data and despite extensive sensitivity analyses."

http://www.bmj.com/content/350/bmj.h3037 

NEJM - "Idarucizumab for Dabigatran Reversal"

"Idarucizumab for Dabigatran Reversal"

"CONCLUSIONS

Idarucizumab completely reversed the anticoagulant effect of dabigatran within minutes. (Funded by Boehringer Ingelheim; RE-VERSE AD ClinicalTrials.gov number, NCT02104947.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1502000?query=featured_home

JAMA - Antibiotic Therapy vs Appendectomy

"Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis"

"Conclusions and Relevance  Among patients with CT-proven, uncomplicated appendicitis, antibiotic treatment did not meet the prespecified criterion for noninferiority compared with appendectomy. Most patients randomized to antibiotic treatment for uncomplicated appendicitis did not require appendectomy during the 1-year follow-up period, and those who required appendectomy did not experience significant complications."

https://jama.jamanetwork.com/article.aspx?articleid=2320315

Weekly Guideline- 2015 AHA ICH

"AHA/ASA Guideline
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage"

http://stroke.ahajournals.org/content/early/2015/05/28/STR.0000000000000069

CIRC - Aortic Dissection with Coronary Procedures

 "Incidence, Management, and Immediate- and Long-Term Outcomes After Iatrogenic Aortic Dissection During Diagnostic or Interventional Coronary Procedures"

"Conclusions—Iatrogenic catheter dissection of the aorta is a rare complication that carries an excellent short- and long-term prognosis with the adoption of a conservative approach. When a coronary artery is involved as an entry point, it usually can be safely sealed with a stent with good long-term outcomes."

http://circ.ahajournals.org/content/131/24/2114.abstract

BMJ - Primary prevention with lipid lowering drugs in the elderly

"Primary prevention with lipid lowering drugs and long term risk of vascular events in older people: population based cohort study"

"Conclusion
In a population based cohort of older people with no history of vascular events, use of statins or fibrates was associated with a 30% decrease in the incidence of stroke."

http://www.bmj.com/content/350/bmj.h2335

NEJM - Dispatch of Laypersons for CPR in Cardiac Arrest

"Mobile-Phone Dispatch of Laypersons for CPR in Out-of-Hospital Cardiac Arrest"

"CONCLUSIONS

A mobile-phone positioning system to dispatch lay volunteers who were trained in CPR was associated with significantly increased rates of bystander-initiated CPR among persons with out-of-hospital cardiac arrest. (Funded by the Swedish Heart–Lung Foundation and Stockholm County; ClinicalTrials.gov number, NCT01789554.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1406038?query=featured_home 

JAMA - Antidepressant Use and Pulmonary Hypertension of the Newborn

"Antidepressant Use Late in Pregnancy and Risk of Persistent Pulmonary Hypertension of the Newborn"

"Conclusions and Relevance  Evidence from this large study of publicly insured pregnant women may be consistent with a potential increased risk of PPHN associated with maternal use of SSRIs in late pregnancy. However, the absolute risk was small, and the risk increase appears more modest than suggested in previous studies."
https://jama.jamanetwork.com/article.aspx?articleid=2300602

Weekly Guideline - 2015 AHA Revised Jones Criteria

"Revision of the Jones Criteria for the Diagnosis of Acute Rheumatic Fever in the Era of Doppler Echocardiography"
""AHA Scientific Statement"

http://circ.ahajournals.org/content/131/20/1806

Lancet - Preventing Cognitive Decline

"A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial"

"Interpretation

Findings from this large, long-term, randomised controlled trial suggest that a multidomain intervention could improve or maintain cognitive functioning in at-risk elderly people from the general population."

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60461-5/fulltext

NEJM - Early CPR Pre-Hospital

 "Early Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest"

"CONCLUSIONS

CPR performed before EMS arrival was associated with a 30-day survival rate after an out-of-hospital cardiac arrest that was more than twice as high as that associated with no CPR before EMS arrival. (Funded by the Laerdal Foundation for Acute Medicine and others.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1405796?query=featured_home

JAMA - MCAT Testing Time and Medical School Performance

"Association of MCAT Scores Obtained With Standard vs Extra Administration Time With Medical School Admission, Medical Student Performance, and Time to Graduation"

"Conclusions and Relevance  Among applicants to US medical schools, those with MCAT scores obtained with extra test administration time, compared with standard administration time, had no significant difference in rate of medical school admission but had lower rates of passing the USMLE Step examinations and of medical school graduation within 4 to 8 years after matriculation. These findings raise questions about the types of learning environments and support systems needed by students who test with extra time on the MCAT to enable them to succeed in medical school."

https://jama.jamanetwork.com/article.aspx?articleid=2319163

Weekly Guideline - 2015 CDC STDs

"Sexually Transmitted Diseases Treatment Guidelines, 2015"

http://www.cdc.gov/mmwr/preview/mmwrhtml/rr6403a1.htm?s_cid=rr6403a1_x

CIRC - Transapical or Transfemoral Transcatheter AVR

"Propensity-Matched Comparisons of Clinical Outcomes After Transapical or Transfemoral Transcatheter Aortic Valve Replacement"

"Conclusions—The likelihood of adverse periprocedural events and prolonged recovery is greater after TA-TAVR than TF-TAVR in vasculopathic patients after accounting for differences in cardiovascular risk factors, although stroke risk is equivalent and aortic regurgitation is less. As smaller delivery systems permit TF-TAVR in many of these patients, we recommend a TF-first access strategy for TAVR when anatomically feasible."

http://circ.ahajournals.org/content/131/22/1989.abstract

BMJ - TMP-SMX v. Vanco for MRSA

"Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused by met[h]icillin resistant Staphylococcus aureus: randomised controlled trial"

"Conclusions High dose trimethoprim-sulfamethoxazole did not achieve non-inferiority to vancomycin in the treatment of severe MRSA infections. The difference was particularly marked for patients with bacteraemia."

http://www.bmj.com/content/350/bmj.h2219

NEJM - Financial-Incentives for Smoking Cessation

"Randomized Trial of Four Financial-Incentive Programs for Smoking Cessation"

"CONCLUSIONS

Reward-based programs were much more commonly accepted than deposit-based programs, leading to higher rates of sustained abstinence from smoking. Group-oriented incentive programs were no more effective than individual-oriented programs. (Funded by the National Institutes of Health and CVS Caremark; ClinicalTrials.gov number, NCT01526265.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1414293 

JAMA - Renal Ischemic Preconditioning in Cardiac Surgery

"Effect of Remote Ischemic Preconditioning on Kidney Injury Among High-Risk Patients Undergoing Cardiac Surgery"

"Conclusions and Relevance  Among high-risk patients undergoing cardiac surgery, remote ischemic preconditioning compared with no ischemic preconditioning significantly reduced the rate of acute kidney injury and use of renal replacement therapy. The observed reduction in the rate of acute kidney injury and the need for renal replacement warrants further investigation."

http://jama.jamanetwork.com/article.aspx?articleid=2299339