Lancet: Diabetes Contol with Gastric Band in the Overweight

"Multidisciplinary diabetes care with and without bariatric surgery in overweight people: a randomised controlled trial"
http://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)70066-X/fulltext
"Interpretation

When added to multidisciplinary care, laparoscopic adjustable gastric band surgery for overweight people with type 2 diabetes improves glycaemic control with an acceptable adverse event profile. Laparoscopic adjustable gastric band surgery is a reasonable treatment option for this population."

NEJM: BP in Septic Shock

"High versus Low Blood-Pressure Target in Patients with Septic Shock"
http://www.nejm.org/doi/full/10.1056/NEJMoa1312173?query=featured_home
"CONCLUSIONS

Targeting a mean arterial pressure of 80 to 85 mm Hg, as compared with 65 to 70 mm Hg, in patients with septic shock undergoing resuscitation did not result in significant differences in mortality at either 28 or 90 days. (Funded by the French Ministry of Health; SEPSISPAM ClinicalTrials.gov number, NCT01149278.)"

JAMA: Maternal BMI

"Maternal Body Mass Index and the Risk of Fetal Death, Stillbirth, and Infant Death"
http://jama.jamanetwork.com/article.aspx?articleid=1860462
"Conclusions and Relevance  Even modest increases in maternal BMI were associated with increased risk of fetal death, stillbirth, and neonatal, perinatal, and infant death. Weight management guidelines for women who plan pregnancies should take these findings into consideration to reduce the burden of fetal death, stillbirth, and infant death."

Weekly Guideline: 2014 ACC AHA A Fib

"2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society"
http://circ.ahajournals.org/content/early/2014/04/10/CIR.0000000000000040.full.pdf+html

http://circ.ahajournals.org/content/early/2014/04/10/CIR.0000000000000041.full.pdf+html

Circ: Antiplatelet for CAD and A Fib

"Antiplatelet Therapy for Stable Coronary Artery Disease in Atrial Fibrillation Patients Taking an Oral Anticoagulant"
http://circ.ahajournals.org/content/129/15/1577.abstract 
"Conclusions—In atrial fibrillation patients with stable coronary artery disease, the addition of antiplatelet therapy to VKA therapy is not associated with a reduction in risk of recurrent coronary events or thromboembolism, whereas risk of bleeding is increased significantly. The common practice of adding antiplatelet therapy to oral VKA anticoagulation in patients with atrial fibrillation and stable coronary artery disease warrants reassessment."

BMJ: Incretin and Pancreatitis Risk with DM-2

"Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies"
http://www.bmj.com/content/348/bmj.g2366
"Conclusions The available evidence suggests that the incidence of pancreatitis among patients using incretins is low and that the drugs do not increase the risk of pancreatitis. Current evidence, however, is not definitive, and more carefully designed and conducted observational studies are warranted to definitively establish the extent, if any, of increased risk."

NEJM  "Aspirin in Patients Undergoing Noncardiac Surgery"  
http://www.nejm.org/doi/full/10.1056/NEJMoa1401105?query=featured_home
"CONCLUSIONS

Administration of aspirin before surgery and throughout the early postsurgical period had no significant effect on the rate of a composite of death or nonfatal myocardial infarction but increased the risk of major bleeding. (Funded by the Canadian Institutes of Health Research and others; POISE-2 ClinicalTrials.gov number,NCT01082874.)"

JAMA  "Validation of the Atherosclerotic Cardiovascular Disease Pooled Cohort Risk Equations"
http://jama.jamanetwork.com/article.aspx?articleid=1853203
"Conclusions and Relevance  In this cohort of US adults for whom statin initiation is considered based on the ACC/AHA Pooled Cohort risk equations, observed and predicted 5-year atherosclerotic CVD risks were similar, indicating that these risk equations were well calibrated in the population for which they were designed to be used, and demonstrated moderate to good discrimination."

Weekly Guideline - Standards of Medical Care in Diabetes 2014

2014 ADA Standards of Medical Care in Diabetes 2014
http://care.diabetesjournals.org/content/37/Supplement_1.toc

Summary of Revisions to the 2014 Clinical Practice Recommendations
http://care.diabetesjournals.org/content/37/Supplement_1/S4.full

Exeutive Summary
http://care.diabetesjournals.org/content/37/Supplement_1/S5.full
PDF
http://care.diabetesjournals.org/content/37/Supplement_1/S5.full.pdf+html

"Type A Aortic Dissection in Marfan Syndrome"
http://circ.ahajournals.org/content/129/13/1381.abstract
"Conclusions—Emergency surgery for type A dissection in patients with Marfan syndrome is associated with low in-hospital mortality. Failure to extend the primary surgery to aortic root or arch repair leads to a highly complex clinical course. Aortic root replacement or repair is highly recommended because supracoronary ascending replacement is associated with a high need (>40%) for root reintervention."

Lancet: Diabetes Care in the Obese +/- Bariatric Surgery

"Multidisciplinary diabetes care with and without bariatric surgery in overweight people: a randomised controlled trial"
Lancet
http://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)70066-X/fulltext 
"Interpretation

When added to multidisciplinary care, laparoscopic adjustable gastric band surgery for overweight people with type 2 diabetes improves glycaemic control with an acceptable adverse event profile. Laparoscopic adjustable gastric band surgery is a reasonable treatment option for this population."

"ABT-450/r–Ombitasvir and Dasabuvir with Ribavirin for Hepatitis C with Cirrhosis"
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1402869?query=featured_home
"CONCLUSIONS

In this phase 3 trial of an oral, interferon-free regimen evaluated exclusively in patients with HCV genotype 1 infection and cirrhosis, multitargeted therapy with the use of three new antiviral agents and ribavirin resulted in high rates of sustained virologic response. Drug discontinuations due to adverse events were infrequent. (Funded by AbbVie; TURQUOISE-II ClinicalTrials.gov number, NCT01704755.)"

"Web-Based Alcohol Screening and Brief Intervention for University Students"
JAMA 
http://jama.jamanetwork.com/article.aspx?articleid=1849990
"Conclusions and Relevance  A national web-based alcohol screening and brief intervention program produced no significant reductions in the frequency or overall volume of drinking or academic problems. There remains a possibility of a small reduction in the amount of alcohol consumed per typical drinking occasion."  

Weely Guideline - 2014 AAP Pediatric Preventive Health Care

2014 AAP "2014 Recommendations for Pediatric Preventive Health Care"
http://pediatrics.aappublications.org/content/133/3/568/F1.expansion.html

"Permanent Leadless Cardiac Pacing
Results of the LEADLESS Trial'
http://circ.ahajournals.org/content/129/14/1466.abstract
"Conclusions—In a prospective nonrandomized study, a completely self-contained, single-chamber leadless cardiac pacemaker has shown to be safe and feasible. The absence of a transvenous lead and subcutaneous pulse generator could represent a paradigm shift in cardiac pacing."

"Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments"
http://www.bmj.com/content/348/bmj.g2545
"Conclusions In prophylactic studies oseltamivir reduces the proportion of symptomatic influenza. In treatment studies it also modestly reduces the time to first alleviation of symptoms, but it causes nausea and vomiting and increases the risk of headaches and renal and psychiatric syndromes. The evidence of clinically significant effects on complications and viral transmission is limited because of rarity of such events and problems with study design. The trade-off between benefits and harms should be borne in mind when making decisions to use oseltamivir for treatment, prophylaxis, or stockpiling."

"Adenoma Detection Rate and Risk of Colorectal Cancer and Death"
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1309086?query=featured_home 
"CONCLUSIONS

The adenoma detection rate was inversely associated with the risks of interval colorectal cancer, advanced-stage interval cancer, and fatal interval cancer. (Funded by the Kaiser Permanente Community Benefit program and the National Cancer Institute.)"

"Health Care–Associated Infection After Red Blood Cell Transfusion"
JAMA
http://jama.jamanetwork.com/article.aspx?articleid=1853162 
"Conclusions and Relevance  Among hospitalized patients, a restrictive RBC transfusion strategy was associated with a reduced risk of health care–associated infection compared with a liberal transfusion strategy. Implementing restrictive strategies may have the potential to lower the incidence of health care–associated infection."

Weekly Guideline: Torsades

2010 AHA/ACC Expert Consensus Document: Prevention of Torsade de Pointes in Hospital Settings
http://content.onlinejacc.org/article.aspx?articleid=1140491

"National Assessment of Warfarin Anticoagulation Therapy for Stroke Prevention in Atrial Fibrillation"
http://circ.ahajournals.org/content/129/13/1407.abstract 
"Conclusion—This study demonstrates widespread suboptimal anticoagulation control, suggesting an urgent need to improve oral anticoagulation care for most patient segments in the United States."  

"Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials"
http://www.bmj.com/content/348/bmj.g2035

 "Aspirin in Patients Undergoing Noncardiac Surgery"
http://www.nejm.org/doi/full/10.1056/NEJMoa1401105?query=featured_home