Weekly Guideline

"2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines"
Circ
http://circ.ahajournals.org/content/early/2013/11/11/01.cir.0000437740.48606.d1.full.pdf+html

"Association Between Exposure to Low to Moderate Arsenic Levels and Incident Cardiovascular Disease"
Annals IM
http://annals.org/article.aspx?articleid=1770701 
"Conclusion: Long-term exposure to low to moderate arsenic levels was associated with cardiovascular disease incidence and mortality."  

"Benefits of Statins in Elderly Subjects Without Established Cardiovascular Disease
A Meta-Analysis"
JACC
http://content.onlinejacc.org/article.aspx?articleid=1732396 
"Conclusions  In elderly subjects at high CV risk without established CV disease, statins significantly reduce the incidence of MI and stroke, but do not significantly prolong survival in the short-term."

"Effect of β blockers on mortality after myocardial infarction in adults with COPD: population based cohort study of UK electronic healthcare records"
BMJ
http://www.bmj.com/content/347/bmj.f6650 
"Conclusions The use of β blockers started either at the time of hospital admission for myocardial infarction or before a myocardial infarction is associated with improved survival after myocardial infarction in patients with COPD."

"Association of Nut Consumption with Total and Cause-Specific Mortality"  
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1307352 

"Effect of Weight Reduction and Cardiometabolic Risk Factor Management on Symptom Burden and Severity in Patients With Atrial Fibrillation" 
JAMA
http://jama.jamanetwork.com/article.aspx?articleid=1779533
"Conclusions and Relevance  In this study, weight reduction with intensive risk factor management resulted in a reduction in atrial fibrillation symptom burden and severity and in beneficial cardiac remodeling. These findings support therapy directed at weight and risk factors in the management of atrial fibrillation."

Weekly Guidelines

"2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines"
Circ
http://circ.ahajournals.org/content/early/2013/11/11/01.cir.0000437741.48606.98.full.pdf+html

"Myocardial Infarction and Ischemic Heart Disease in Overweight and Obesity With and Without Metabolic Syndrome" 
JAMA IM
http://archinte.jamanetwork.com/article.aspx?articleid=1770522 
"Conclusions and Relevance  These findings suggest that overweight and obesity are risk factors for MI and IHD regardless of the presence or absence of metabolic syndrome and that metabolic syndrome is no more valuable than BMI in identifying individuals at risk."

"Automated External Defibrillators Inaccessible to More Than Half of Nearby Cardiac Arrests in Public Locations During Evening, Nighttime, and Weekends"
Circ
http://circ.ahajournals.org/content/128/20/2224.abstract
"Conclusions—Limited AED accessibility at the time of cardiac arrest decreased AED coverage by 53.4% during the evening, nighttime, and weekends, which is when 61.8% of all cardiac arrests in public locations occurred. Thus, not only strategic placement but also uninterrupted AED accessibility warrant attention if public-access defibrillation is to improve survival after out-of-hospital cardiac arrest."

"Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study"
Lancet
http://www.thelancet.com/journals/landia/article/PIIS2213-8587(13)70156-6/fulltext
"Interpretation  

Lower resting energy expenditure, non-shivering thermogenesis, and BAT volumes in south Asian populations might underlie their high susceptibility to metabolic disturbances, such as obesity and type 2 diabetes. Development of strategies to increase BAT volume and activity might help prevent and treat such disorders, particularly in south Asian individuals."

"Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest"  
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1310519?query=featured_home   
"CONCLUSIONS  

In unconscious survivors of out-of-hospital cardiac arrest of presumed cardiac cause, hypothermia at a targeted temperature of 33°C did not confer a benefit as compared with a targeted temperature of 36°C."

"Outcomes Following Transcatheter Aortic Valve Replacement in the United States"
JAMA
http://jama.jamanetwork.com/article.aspx?articleid=1779535 
"Conclusions and Relevance  Among patients undergoing TAVR at US centers in the STS/ACC TVT Registry, device implantation success was achieved in 92% of cases, the overall in-hospital mortality rate was 5.5%, and the stroke rate was 2.0%. Although these postmarket US approval findings are comparable with prior published trial data and international experience, long-term follow-up is essential to assess continued efficacy and safety."

Weekly Guidelines - Obesity, Lipids, Back Pain

"Diagnosis and Treatment of Low Back Pain: A Joint Clinical Practice Guideline from the American College of Physicians and the American Pain Society" 
Annals IM
http://annals.org/article.aspx?articleid=736814

"2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines"
Circ
http://circ.ahajournals.org/content/early/2013/11/11/01.cir.0000437738.63853.7a.full.pdf+html

"2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society"
Circ
http://circ.ahajournals.org/content/early/2013/11/11/01.cir.0000437739.71477.ee.full.pdf+html

"Gabapentin Treatment for Alcohol Dependence"
JAMA IM Nov 4
http://archinte.jamanetwork.com/article.aspx?articleid=1764009 
"Conclusions and Relevance  Gabapentin (particularly the 1800-mg dosage) was effective in treating alcohol dependence and relapse-related symptoms of insomnia, dysphoria, and craving, with a favorable safety profile. Increased implementation of pharmacological treatment of alcohol dependence in primary care may be a major benefit of gabapentin as a treatment option for alcohol dependence."

"2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines" 
Circ
http://circ.ahajournals.org/content/early/2013/11/11/01.cir.0000437738.63853.7a.full.pdf+html

"Perinatal outcomes after bariatric surgery: nationwide population based matched cohort study"  
BMJ
http://www.bmj.com/content/347/bmj.f6460 
"Conclusion Women with a history of bariatric surgery were at increased risk of preterm and small for gestational age births and should be regarded as a risk group during pregnancy."

"Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy"  "The study was stopped because of increased risks of hyperkalemia and acute kidney injury with combination therapy."
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1303154?query=featured_home 
"CONCLUSIONS

Combination therapy with an ACE inhibitor and an ARB was associated with an increased risk of adverse events among patients with diabetic nephropathy."

"Association of Testosterone Therapy With Mortality, Myocardial Infarction, and Stroke in Men With Low Testosterone Levels"
JAMA Nov 5
http://jama.jamanetwork.com/article.aspx?articleid=1764051
"Conclusions and Relevance  Among a cohort of men in the VA health care system who underwent coronary angiography and had a low serum testosterone level, the use of testosterone therapy was associated with increased risk of adverse outcomes. These findings may inform the discussion about the potential risks of testosterone therapy."

Weekly Guideline

"AHA Scientific Statement
Beyond Medications and Diet: Alternative Approaches to Lowering Blood Pressure"     Hypertension
http://hyper.ahajournals.org/content/early/2013/04/22/HYP.0b013e318293645f

"Better Diet Quality and Decreased Mortality Among Myocardial Infarction Survivors"
JAMA IM
http://archinte.jamanetwork.com/article.aspx?articleid=1733453
"Conclusions and Relevance  Myocardial infarction survivors who consume a higher-quality diet, which has been associated with a lower risk of coronary heart disease in primary prevention, have lower subsequent all-cause mortality."

"Low Levels of High-Density Lipoprotein Cholesterol and Increased Risk of Cardiovascular Events in Stable Ischemic Heart Disease Patients"  
JACC
http://content.onlinejacc.org/article.aspx?articleid=1731137
"Conclusions  In this post-hoc analysis, patients with SIHD continued to experience incremental cardiovascular risk associated with low HDL-C levels despite OMT during long-term follow-up. This relationship persisted and appeared more prominent even when LDL-C was reduced to optimal levels with intensive dyslipidemic therapy."

"Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR):
an open-label, randomised, phase 2 trial"
Lancet
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)62121-2/fulltext
"Interpretation

These findings suggest that the fixed-dose combination of sofosbuvir-ledipasvir alone or with ribavirin has the potential to cure most patients with genotype-1 HCV, irrespective of treatment history or the presence of compensated cirrhosis. Further clinical trials are needed to establish the best treatment duration and to further assess the contribution of ribavirin."

"Autologous Transplantation as Consolidation for Aggressive Non-Hodgkin's Lymphoma"
NEJM
"CONCLUSIONS

Early autologous stem-cell transplantation improved progression-free survival among patients with high-intermediate-risk or high-risk disease who had a response to induction therapy. Overall survival after transplantation was not improved, probably because of the effectiveness of salvage transplantation."
http://www.nejm.org/doi/full/10.1056/NEJMoa1301077

"Effect of Statin Therapy on Mortality in Patients With Ventilator-Associated Pneumonia"
JAMA Oct 23/30
http://jama.jamanetwork.com/article.aspx?articleid=1752244 
"Conclusions and Relevance  In adults with suspected VAP, adjunctive simvastatin therapy compared with placebo did not improve day-28 survival. These findings do not support the use of statins with the goal of improving VAP outcomes."

Weekly Guideline

"Screening, Monitoring, and Treatment of Stage 1 to 3 Chronic Kidney Disease"
Annals Oct 2013
http://annals.org/article.aspx?articleid=1757302

"A 2-Hour Diagnostic Protocol for Possible Cardiac Chest Pain in the Emergency Department"
JAMA IM Nov 1
http://archinte.jamanetwork.com/article.aspx?articleid=1748796 
"Conclusions and Relevance  Using the accelerated diagnostic protocol in the experimental pathway almost doubled the proportion of patients with chest pain discharged early. Clinicians could discharge approximately 1 of 5 patients with chest pain to outpatient follow-up monitoring in less than 6 hours. This diagnostic strategy could be easily replicated in other centers because no extra resources are required."