JAMA - "Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes The SCALE Diabetes Randomized Clinical Trial"

"Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes The SCALE Diabetes Randomized Clinical Trial"

"Conclusions and Relevance  Among overweight and obese participants with type 2 diabetes, use of subcutaneous liraglutide (3.0 mg) daily, compared with placebo, resulted in weight loss over 56 weeks. Further studies are needed to evaluate longer-term efficacy and safety."

http://jama.jamanetwork.com/article.aspx?articleid=2428956

Weekly Guideline - 2015 AAP "The Role of the Pediatrician in Primary Prevention of Obesity"

"The Role of the Pediatrician in Primary Prevention of Obesity"

http://pediatrics.aappublications.org/content/136/1/e275.abstract?rss=1

http://pediatrics.aappublications.org/content/136/1/e275.full.pdf+html (PDF)

CIRC - "Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease"

"Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease"

"Conclusions
—More than a quarter of the patients in ARISTOTLE with nonvalvular atrial fibrillation had moderate or severe valvular heart disease. There was no evidence of a differential effect of apixaban over warfarin in reducing stroke or systemic embolism, causing less bleeding, and reducing death in patients with and without valvular heart disease."

http://circ.ahajournals.org/content/132/8/624.abstract

BMJ - "Comparative effectiveness and tolerance of treatments for Helicobacter pylori: systematic review and network meta-analysis"

"Comparative effectiveness and tolerance of treatments for Helicobacter pylori: systematic review and network meta-analysis"

"Conclusion
Comparison of different eradication treatments for H pylori showed that concomitant treatments, 10 or 14 days of probiotic supplemented triple treatment, 10 or 14 days of levofloxacin based triple treatment, 14 days of hybrid treatment, and 10 or 14 days of sequential treatment might be better alternatives for the eradication of H pylori."

http://www.bmj.com/content/351/bmj.h4052 

NEJM - "Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes The SCALE Diabetes Randomized Clinical Trial"

"Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes The SCALE Diabetes Randomized Clinical Trial"

"CONCLUSIONS

The prevalence of occult cancer was low among patients with a first unprovoked venous thromboembolism. Routine screening with CT of the abdomen and pelvis did not provide a clinically significant benefit. (Funded by the Heart and Stroke Foundation of Canada; SOME ClinicalTrials.gov number, NCT00773448.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1506623

JAMA - "Association of Electronic Cigarette Use With Initiation of Combustible Tobacco Product Smoking in Early Adolescence"

"Association of Electronic Cigarette Use With Initiation of Combustible Tobacco Product Smoking in Early Adolescence"

"Conclusions and Relevance  Among high school students in Los Angeles, those who had ever used e-cigarettes at baseline compared with nonusers were more likely to report initiation of combustible tobacco use over the next year. Further research is needed to understand whether this association may be causal."

http://jama.jamanetwork.com/article.aspx?articleid=2428954

Weekly Guideline - 2012 "NASPGHAN Practice Guidelines: Diagnosis and Management of Hepatitis C Infection in Infants, Children, and Adolescents"

"NASPGHAN Practice Guidelines: Diagnosis and Management of Hepatitis C Infection in Infants, Children, and Adolescents"

http://www.naspghan.org//files/documents/pdfs/position-papers/NASPGHAN_Practice_Guidelines___Diagnosis_and.30[1].pdf

CIRC - "Arrhythmic Mitral Valve Prolapse and Sudden Cardiac Death"

"Arrhythmic Mitral Valve Prolapse and Sudden Cardiac Death"

"Conclusions—MVP is an underestimated cause of arrhythmic SCD, mostly in young adult women. Fibrosis of the papillary muscles and inferobasal left ventricular wall, suggesting a myocardial stretch by the prolapsing leaflet, is the structural hallmark and correlates with ventricular arrhythmias origin. Contrast-enhanced cardiac magnetic resonance may help to identify in vivo this concealed substrate for risk stratification."

http://circ.ahajournals.org/content/132/7/556.full

BMJ - "Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies"

"Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies"

"Conclusions Saturated fats are not associated with all cause mortality, CVD, CHD, ischemic stroke, or type 2 diabetes, but the evidence is heterogeneous with methodological limitations. Trans fats are associated with all cause mortality, total CHD, and CHD mortality, probably because of higher levels of intake of industrial trans fats than ruminant trans fats. Dietary guidelines must carefully consider the health effects of recommendations for alternative macronutrients to replace trans fats and saturated fats."

http://www.bmj.com/content/351/bmj.h3978 

NEJM - "Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma"

"Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma"

"CONCLUSIONS

Patients with relapsed or refractory multiple myeloma who received a combination of elotuzumab, lenalidomide, and dexamethasone had a significant relative reduction of 30% in the risk of disease progression or death. (Funded by Bristol-Myers Squibb and AbbVie Biotherapeutics; ELOQUENT-2 ClinicalTrials.gov number,NCT01239797.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1505654

JAMA - "Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels"

 "Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels"

"Conclusions and Relevance  Among older men with low or low-normal testosterone levels, testosterone administration for 3 years vs placebo did not result in a significant difference in the rates of change in either common carotid artery intima-media thickness or coronary artery calcium nor did it improve overall sexual function or health-related quality of life. Because this trial was only powered to evaluate atherosclerosis progression, these findings should not be interpreted as establishing cardiovascular safety of testosterone use in older men."

http://jama.jamanetwork.com/article.aspx?articleid=2425744

Weekly Guideline - 2014 ATS ICU Weakness

"An Official American Thoracic Society Clinical Practice Guideline: The Diagnosis of Intensive Care Unit–acquired Weakness in Adults"

http://www.thoracic.org/statements/resources/cc/ICUAW_cpg.pdf

CIRC - "Prognostic Importance of Impaired Systolic Function in Heart Failure With Preserved Ejection Fraction and the Impact of Spironolactone"

"Prognostic Importance of Impaired Systolic Function in Heart Failure With Preserved Ejection Fraction and the Impact of Spironolactone"

"Conclusions—Impaired left ventricular systolic function is a powerful predictor of HF hospitalization, cardiovascular death, or aborted cardiac arrest in HFpEF independent of clinical predictors. Impaired LS represents a novel imaging biomarker to identify patients with HFpEF at particularly high risk for cardiovascular morbidity and mortality."

http://circ.ahajournals.org/content/132/5/402.abstract

BMJ - "Long term outcomes of transplantation using kidneys from expanded criteria donors: prospective, population based cohort study"

 "Long term outcomes of transplantation using kidneys from expanded criteria donors: prospective, population based cohort study"

"Conclusions Circulating DSA and cold ischaemia time are the main independent determinants of outcome from ECD transplantation. Allocation policies to avoid DSA and reduction of cold ischaemia time to increase efficacy could promote wider implement of ECD transplantation in the context of organ shortage and improve its prognosis."

http://www.bmj.com/content/351/bmj.h3557 

NEJM - "Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults"

"Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults"

"CONCLUSIONS

The incidence of community-acquired pneumonia requiring hospitalization was highest among the oldest adults. Despite current diagnostic tests, no pathogen was detected in the majority of patients. Respiratory viruses were detected more frequently than bacteria. (Funded by the Influenza Division of the National Center for Immunizations and Respiratory Diseases.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1500245

JAMA - "Brief Motivational Intervention for Intimate Partner Violence and Heavy Drinking in the Emergency Department A Randomized Clinical Trial"

"Brief Motivational Intervention for Intimate Partner Violence and Heavy Drinking in the Emergency Department A Randomized Clinical Trial"

"Conclusions and Relevance  For women experiencing IPV and heavy drinking, the use of a brief motivational intervention in the ED compared with assessed and no-contact controls did not significantly reduce the days of heavy drinking or incidents of IPV. These findings do not support a brief motivational intervention in this setting."

https://jama.jamanetwork.com/article.aspx?articleid=2422543

Weekly Guideline - 2014 ERS / ATS Severe Asthma

"Official European Respiratory Society / American Thoracic Society Clinical Practice Guidelines on the Definition, Evaluation, and Treatment of Severe Asthma: An Executive Summary (2014)"

http://www.thoracic.org/statements/resources/allergy-asthma/Severe-Asthma-CPG-ERJ.pdf

CIRC - "Percutaneous Coronary Intervention at Centers With and Without On-Site Surgical Backup An Updated Meta-Analysis of 23 Studies"

"Percutaneous Coronary Intervention at Centers With and Without On-Site Surgical Backup An Updated Meta-Analysis of 23 Studies"

"Conclusions—Clinical outcomes and complication rates of PCI at centers without on-site surgery did not differ from those with on-site surgery, for both primary and nonprimary PCI. Temporal trends indicated improving clinical outcomes in nonprimary PCI at centers without on-site surgery."

http://circ.ahajournals.org/content/132/5/388.abstract

BMJ - "Comparative efficacy of interventions to promote hand hygiene in hospital: systematic review and network meta-analysis"

"Comparative efficacy of interventions to promote hand hygiene in hospital: systematic review and network meta-analysis"

"Conclusion Promotion of hand hygiene with WHO-5 is effective at increasing compliance in healthcare workers. Addition of goal setting, reward incentives, and accountability strategies can lead to further improvements. Reporting of resources required for such interventions remains inadequate."

http://www.bmj.com/content/351/bmj.h3728 

NEJM - "Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function"

"Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function"

"CONCLUSIONS

Mild hypothermia, as compared with normothermia, in organ donors after declaration of death according to neurologic criteria significantly reduced the rate of delayed graft function among recipients. (Funded by the Health Resources and Services Administration; ClinicalTrials.gov number, NCT01680744.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1501969?query=featured_home

JAMA - "Mortality, Hospitalizations, and Expenditures for the Medicare Population Aged 65 Years or Older, 1999-2013"

"Mortality, Hospitalizations, and Expenditures for the Medicare Population Aged 65 Years or Older, 1999-2013"

"Conclusions and Relevance  Among Medicare fee-for-service beneficiaries aged 65 years or older, all-cause mortality rates, hospitalization rates, and expenditures per beneficiary decreased from 1999 to 2013. In the last 6 months of life, total hospitalizations and inpatient expenditures decreased in recent years."

https://jama.jamanetwork.com/article.aspx?articleid=2411282