Tuesday, April 30, 2013

"2013 ACCF/ACR/ASE/ASNC/SCCT/SCMR Appropriate Utilization of Cardiovascular Imaging in Heart Failure""A Joint Report of the American College of Radiology Appropriateness Criteria Committee and the American College of Cardiology Foundation Appropriate Use Criteria Task Force"
JACC April 2013
http://content.onlinejacc.org/article.aspx?articleID=1681370

Monday, April 29, 2013

"Long-Term Safety and Effectiveness of Mechanical Versus Biologic Aortic Valve Prostheses in Older Patients"
Circ Mar 28
http://circ.ahajournals.org/content/127/16/1647.full 
"Conclusions—Among patients undergoing aortic valve replacement, long-term mortality rates were similar for those who received bioprosthetic versus mechanical valves. Bioprostheses were associated with a higher long-term risk of reoperation and endocarditis but a lower risk of stroke and hemorrhage. These risks varied as a function of a patient’s age and comorbidities."

Saturday, April 27, 2013

"Effects of an Acute Care for Elders Unit on Costs and 30-Day Readmissions"
JAMA IM April 22
http://archinte.jamanetwork.com/article.aspx?articleid=1680136 
"Participants  Hospitalists' patients aged 70 years or older spending the entirety of their hospitalization in either the ACE or UC unit in fiscal year 2010."
"Conclusions and Relevance  The ACE unit team model reduces costs and 30-day readmissions. In an era when improving care processes while reducing costs is a vital objective for the Medicare program and our nation as a whole, the ACE model meets these goals."

Friday, April 26, 2013

"Screening for and Treatment of Suicide Risk Relevant to Primary Care: A Systematic Review for the U.S. Preventive Services Task Force" 
Annals April 23
http://annals.org/article.aspx?articleid=1681063 
"Conclusion: Primary care–feasible screening tools might help to identify some adults at increased risk for suicide but have limited ability to detect suicide risk in adolescents. Psychotherapy may reduce suicide attempts in some high-risk adults, but effective interventions for high-risk adolescents are not yet proven."

Thursday, April 25, 2013

"Diagnosis and Management of Q Fever — United States, 2013: Recommendations from CDC and the Q Fever Working Group" 
CDC MMWR Mar 29, 2013
http://www.cdc.gov/mmwr/preview/mmwrhtml/rr6203a1.htm?s_cid=rr6203a1_w

Wednesday, April 24, 2013

"Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23—01): a phase 3 randomised controlled trial"  
Lancet April 2013
http://www.lancet.com/journals/lanonc/article/PIIS1470-2045(13)70035-4/fulltext 
"Interpretation

Axillary dissection could be avoided in patients with early breast cancer and limited sentinel-node involvement, thus eliminating complications of axillary surgery with no adverse effect on survival.  

Funding

None."

Tuesday, April 23, 2013

"Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study" 
BMJ April 19
http://www.bmj.com/content/346/bmj.f2059
"Conclusions In utero exposure to both SSRIs and non-selective monoamine reuptake inhibitors (tricyclic antidepressants) was associated with an increased risk of autism spectrum disorders, particularly without intellectual disability. Whether this association is causal or reflects the risk of autism with severe depression during pregnancy requires further research. However, assuming causality, antidepressant use during pregnancy is unlikely to have contributed significantly towards the dramatic increase in observed prevalence of autism spectrum disorders as it explained less than 1% of cases."

Saturday, April 20, 2013

Friday, April 19, 2013

"Effect of an Investigational Vaccine for PreventingStaphylococcus aureus Infections After Cardiothoracic Surgery

A Randomized Trial"

JAMA April 3
http://jama.jamanetwork.com/article.aspx?articleid=1674236

Wednesday, April 17, 2013

Tuesday, April 16, 2013

"Short-Term Outcomes of Screening Mammography Using Computer-Aided DetectionA Population-Based Study of Medicare Enrollees"
Annals IM April 16
http://annals.org/article.aspx?articleid=1676453 

"Impact of Providing Fee Data on Laboratory Test Ordering"  
JAMA IM April 15
http://archinte.jamanetwork.com/article.aspx?articleid=1678807 

Monday, April 15, 2013

"Long Term Survival of Patients Undergoing Mitral Valve Repair and Replacement: A Longitudinal Analysis of Medicare Fee-for-Service Beneficiaries" 
Circ April 8
http://circ.ahajournals.org/content/early/2013/04/08/CIRCULATIONAHA.113.002200.abstract 
"Conclusions—Mitral valve surgery in the Medicare population carries less risk than previously reported. Given the favorable outcomes of elderly patients undergoing mitral valve surgery, and especially mitral valve repair, an approach of earlier identification and surgical referral appears justified regardless of age."

"
Transcatheter Aortic Valve Implantation for Pure Severe Native Aortic Valve Regurgitation" 
JACC April 2013 http://content.onlinejacc.org/article.aspx?articleid=1654982 
"Conclusions  This registry analysis demonstrates the feasibility and potential procedure difficulties when using TAVI for severe NAVR. Acceptable results may be achieved in carefully selected patients who are deemed too high risk for conventional surgery, but the possibility of requiring 2 valves and leaving residual aortic regurgitation remain important considerations.

Saturday, April 13, 2013

"Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study" 
Lancet April 9
http://www.lancet.com/journals/laneur/article/PIIS1474-4422(13)70067-X/fulltext

"Orlistat and the risk of acute liver injury: self controlled case series study in UK Clinical Practice Research Datalink"
BMJ April 12
http://www.bmj.com/content/346/bmj.f1936

Thursday, April 11, 2013

"Combination Antifungal Therapy for Cryptococcal Meningitis"  
NEJM April 10
http://www.nejm.org/doi/full/10.1056/NEJMoa1110404?query=featured_home 
"CONCLUSIONS

Amphotericin B plus flucytosine, as compared with amphotericin B alone, is associated with improved survival among patients with cryptococcal meningitis. A survival benefit of amphotericin B plus fluconazole was not found. (Funded by the Wellcome Trust and the British Infection Society; Controlled-Trials.com number, ISRCTN95123928.)"

Wednesday, April 10, 2013

"Long QT Syndrome–Associated Mutations in Intrauterine Fetal Death"
JAMA April 10
http://jama.jamanetwork.com/article.aspx?articleid=1677373
"Conclusions and Relevance  In this molecular genetic evaluation of 91 cases of intrauterine fetal death, missense mutations associated with LQTS susceptibility were discovered in 3 cases (3.3%) and overall, genetic variants leading to dysfunctional LQTS-associated ion channels in vitro were discovered in 8 cases (8.8%). These preliminary findings may provide insights into mechanisms of some cases of stillbirth."

Monday, April 8, 2013

"Effect of Metoprolol Versus Carvedilol on Outcomes in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy)" 
JACC April 2013
http://content.onlinejacc.org/article.aspx?articleid=1673446

Sunday, April 7, 2013

"Management of Patients With Atrial Fibrillation
(Compilation of 2006 ACCF/AHA/ESC and 2011 ACCF/AHA/HRS Recommendations)"
Circ April 1
http://circ.ahajournals.org/content/early/2013/04/01/CIR.0b013e318290826d.full.pdf+html

"Use of Glucocorticoids and Risk of Venous Thromboembolism"
JAMA IM April 1
http://archinte.jamanetwork.com/article.aspx?articleid=1673744

Friday, April 5, 2013

"Individual- Versus Group-Based Financial Incentives for Weight Loss"
Annals Int Med April 2
http://annals.org/article.aspx?articleid=1671710

Thursday, April 4, 2013

"Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study"
Lancet April 2013
http://www.lancet.com/journals/laneur/article/PIIS1474-4422(13)70044-9/fulltext

Wednesday, April 3, 2013

"Clinical prediction model to aid emergency doctors managing febrile children at risk of serious bacterial infections: diagnostic study" 
BMJ Mar 1
http://www.bmj.com/content/346/bmj.f1706