"A Systematic Assessment of Benefits and Risks to Guide Breast Cancer Screening Decisions"
http://jama.jamanetwork.com/article.aspx?articleid=1853165

Weekly Guidelines: Infective Endocarditis Guidelines

2010 AHA Scientific Statement Update on Cardiovascular Implantable Electronic Device Infections and Their Management
http://circ.ahajournals.org/content/121/3/458.full.pdf

2008 ACC/AHA Guideline Update on Valvular Heart Disease: Focused Update on Infective Endocarditis
http://circ.ahajournals.org/content/118/8/887.full.pdf


2007 AHA Prevention of Infective Endocarditis
http://circ.ahajournals.org/content/116/15/1736.full.pdf


2005 AHA Scientific Statement Infective Endocarditis
http://circ.ahajournals.org/content/111/23/3167.full

"Survival Benefit From Transplantation in Patients Listed for Heart Transplantation in the United States"
JACC April 2014
http://jacc.org/
"Conclusions  The risk for waiting list mortality varies considerably among HT candidates. Although the survival benefit of HT generally increases with increasing risk for waiting list mortality, there is no measurable benefit in many candidates at the lower end of the risk spectrum."

"Nicotine patches in pregnant smokers: randomised, placebo controlled, multicentre trial of efficacy"
BMJ
http://www.bmj.com/content/348/bmj.g1622 
"Conclusion The nicotine patch did not increase either smoking cessation rates or birth weights despite adjustment of nicotine dose to match levels attained when smoking, and higher than usual doses."

"Ribavirin for Chronic Hepatitis E Virus Infection in Transplant Recipients"
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1215246 
"CONCLUSIONS

This retrospective, multicenter study showed that ribavirin as monotherapy may be effective in the treatment of chronic HEV infection; a 3-month course seemed to be an appropriate duration of therapy for most patients."

"Age-Adjusted D-Dimer Cutoff Levels to Rule Out Pulmonary Embolism
The ADJUST-PE Study"
http://jama.jamanetwork.com/article.aspx?articleid=1841967
"Conclusions and Relevance  Compared with a fixed D-dimer cutoff of 500 µg/L, the combination of pretest clinical probability assessment with age-adjusted D-dimer cutoff was associated with a larger number of patients in whom PE could be considered ruled out with a low likelihood of subsequent clinical venous thromboembolism."

Weekly Guideline: Valvular Heart Disease

"2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines"
http://circ.ahajournals.org/content/early/2014/02/27/CIR.0000000000000029.full.pdf+html


"2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines"
http://circ.ahajournals.org/content/early/2014/02/27/CIR.0000000000000031.full.pdf+html

"Sodium Excretion and Risk of Developing Coronary Heart Disease"
Circ
http://circ.ahajournals.org/content/129/10/1121.abstract 
"Conclusions—Overall, there was no association between sodium excretion and risk of CHD. The association between sodium excretion and CHD risk was modified by NT-proBNP. Higher sodium excretion was associated with an increased CHD risk among subjects with increased NT-proBNP concentrations or with hypertension."

"Associations between exposure to takeaway food outlets, takeaway food consumption, and body weight in Cambridgeshire, UK"
BMJ
http://www.bmj.com/content/348/bmj.g1464 
"Conclusions Exposure to takeaway food outlets in home, work, and commuting environments combined was associated with marginally higher consumption of takeaway food, greater body mass index, and greater odds of obesity. Government strategies to promote healthier diets through planning restrictions for takeaway food could be most effective if focused around the workplace."  

"Introduction of Surgical Safety Checklists in Ontario, Canada"  
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMsa1308261?query=featured_home   
"CONCLUSIONS 

Implementation of surgical safety checklists in Ontario, Canada, was not associated with significant reductions in operative mortality or complications. (Funded by the Canadian Institutes of Health Research.)"

"Prevalence, Characteristics, and Publication of Discontinued Randomized Trials"
JAMA
http://jama.jamanetwork.com/article.aspx?articleid=1840235 
"Conclusions and Relevance  In this sample of trials based on RCT protocols from 6 research ethics committees, discontinuation was common, with poor recruitment being the most frequently reported reason. Greater efforts are needed to ensure the reporting of trial discontinuation to research ethics committees and the publication of results of discontinued trials."  

Weekly Guideline: Fibromuscular Dysplasia

"AHA Scientific Statement Fibromuscular Dysplasia: State of the Science and Critical Unanswered Questions"
Circ
http://circ.ahajournals.org/content/129/9/1048.extract

"ST-Segment Elevation Myocardial Infarction Treated by Radial or Femoral Approach in a Multicenter Randomized Clinical Trial"
JACC March 2014
J Am Coll Cardiol. 2014;63(10):964-972. doi:10.1016/j.jacc.2013.08.1651
http://jacc.org/ 
"Conclusions  In patients with STEMI undergoing primary PCI by operators experienced in both access sites, the radial approach was associated with significantly lower incidence of major bleeding and access site complications and superior net clinical benefit. These findings support the use of the radial approach in primary PCI as first choice after proper training. (Trial Comparing Radial and Femoral Approach in Primary Percutaneous Coronary Intervention [PCI] [STEMI-RADIAL]; NCT01136187)"  

"Exclusion of deep vein thrombosis using the Wells rule in clinically important subgroups: individual patient data meta-analysis"
BMJ
http://www.bmj.com/content/348/bmj.g366/rr/689698
"Conclusion Combined with a negative D-dimer test result (both quantitative and qualitative), deep vein thrombosis can be excluded in patients with an unlikely score on the Wells rule. This finding is true for both sexes, as well as for patients presenting in primary and hospital care. In patients with cancer, the combination is neither safe nor efficient. For patients with suspected recurrent disease, one extra point should be added to the rule to enable a safe exclusion."

"Radical Prostatectomy or Watchful Waiting in Early Prostate Cancer"
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1311593 
"CONCLUSIONS

Extended follow-up confirmed a substantial reduction in mortality after radical prostatectomy; the number needed to treat to prevent one death continued to decrease when the treatment was modified according to age at diagnosis and tumor risk. A large proportion of long-term survivors in the watchful-waiting group have not required any palliative treatment. (Funded by the Swedish Cancer Society and others.)"

"Warfarin, Kidney Dysfunction, and Outcomes Following Acute Myocardial Infarction in Patients With Atrial Fibrillation"
JAMA
http://jama.jamanetwork.com/article.aspx?articleid=1835505 
"Conclusions and Relevance  Warfarin treatment was associated with a lower 1-year risk for the composite outcome of death, MI, and ischemic stroke without a higher risk of bleeding in consecutive acute MI patients with atrial fibrillation. This association was not related to the severity of concurrent CKD."  

Weekly Guideline: Antiretroviral Adherence for Persons With HIV

"Guidelines for Improving Entry Into and Retention in Care and Antiretroviral Adherence for Persons With HIV: Evidence-Based Recommendations From an International Association of Physicians in AIDS Care Panel"
Annals 2012
http://annals.org/article.aspx?articleid=1170890

"Factors Associated With Major Bleeding Events Insights From the ROCKET AF Trial (Rivaroxaban Once-daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation)"
JACChttp://jacc.org/
Volume 63, Issue 9, March 2014 
"Conclusions  Rivaroxaban and warfarin had similar risk for major/nonmajor clinically relevant bleeding. Age, sex, DBP, prior GI bleeding, prior acetylsalicylic acid use, and anemia were associated with the risk of major bleeding. (An Efficacy and Safety Study of Rivaroxaban With Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Patients With Non-Valvular Atrial Fibrillation: NCT00403767)"

"Effectiveness of quadrivalent human papillomavirus vaccine for the prevention of cervical abnormalities"
http://www.bmj.com/content/348/bmj.g1458

"DNA Sequencing versus Standard Prenatal Aneuploidy Screening"
NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1311037?query=featured_home 
"CONCLUSIONS

In a general obstetrical population, prenatal testing with the use of cfDNA had significantly lower false positive rates and higher positive predictive values for detection of trisomies 21 and 18 than standard screening. (Funded by Illumina; ClinicalTrials.gov number,NCT01663350.)"

"Prevalence of Childhood and Adult Obesity in the United States, 2011-2012"
http://jama.jamanetwork.com/article.aspx?articleid=1832542
"Conclusions and Relevance  Overall, there have been no significant changes in obesity prevalence in youth or adults between 2003-2004 and 2011-2012. Obesity prevalence remains high and thus it is important to continue surveillance."  

Weekly Guideline: 2014 AAN A Fib

Weekly Guideline: A Fib

2014 AAN "Summary of evidence-based guideline update: Prevention of stroke in nonvalvular atrial fibrillation"
Neurology
http://www.neurology.org/content/82/8/716.short