Weekly Guideline - 2015 NCI Breast CA

"Breast Cancer Treatment–for health professionals (PDQ®)"
http://www.cancer.gov/types/breast/hp/breast-treatment-pdq#section/_1

CIRC - "Sex Differences in the Rate, Timing, and Principal Diagnoses of 30-Day Readmissions in Younger Patients with Acute Myocardial Infarction"

"Sex Differences in the Rate, Timing, and Principal Diagnoses of 30-Day Readmissions in Younger Patients with Acute Myocardial Infarction"

"Conclusions—In comparison with men, younger women have a higher risk for readmission, even after the adjustment for confounders. The timing of 30-day readmission was similar in women and men, and both sexes were susceptible to a wide range of causes for readmission."

http://circ.ahajournals.org/content/132/3/158.abstract

BMJ - "Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs: nationwide propensity score matched study"

"Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs: nationwide propensity score matched study"

"Conclusions Combined use of antidepressants and NSAIDs was associated with an increased risk of intracranial haemorrhage within 30 days of initial combination."
http://www.bmj.com/content/351/bmj.h3517 

NEJM - "Long-Term Outcomes of Abdominal Aortic Aneurysm in the Medicare Population"

"Long-Term Outcomes of Abdominal Aortic Aneurysm in the Medicare Population"

"CONCLUSIONS

Endovascular repair, as compared with open repair, of abdominal aortic aneurysm was associated with a substantial early survival advantage that gradually decreased over time. The rate of late rupture was significantly higher after endovascular repair than after open repair. The outcomes of endovascular repair have been improving over time. (Funded by the National Institutes of Health.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1405778?query=featured_home

Weekly Guideline: 2014 AAP "Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis"

"Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis"

http://pediatrics.aappublications.org/content/134/5/e1474.abstract?sid=9744b05c-624f-4f66-b2af-968df16aa613

CIRC - "Association of Discharge Aspirin Dose With Outcomes After Acute Myocardial Infarction"

"Association of Discharge Aspirin Dose With Outcomes After Acute Myocardial Infarction"

"Conclusions—Among percutaneous coronary intervention–treated patients with myocardial infarction, high-maintenance-dose aspirin was associated with similar rates of major adverse cardiovascular events, but a greater risk of minor bleeding than those discharged on low-dose aspirin."

http://circ.ahajournals.org/content/132/3/174.abstract

BMJ - Sugary & Artificially Sweetened Drinks and DM-2: Meta-analysis

"Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction"

"Conclusions Habitual consumption of sugar sweetened beverages was associated with a greater incidence of type 2 diabetes, independently of adiposity. Although artificially sweetened beverages and fruit juice also showd positive associations with incidence of type 2 diabetes, the findings were likely to involve bias. None the less, both artificially sweetened beverages and fruit juice were unlikely to be healthy alternatives to sugar sweetened beverages for the prevention of type 2 diabetes. Under assumption of causality, consumption of sugar sweetened beverages over years may be related to a substantial number of cases of new onset diabetes."

http://www.bmj.com/content/351/bmj.h3576 

NEJM - "Regional Nodal Irradiation in Early-Stage Breast Cancer"

"Regional Nodal Irradiation in Early-Stage Breast Cancer"

"CONCLUSIONS

Among women with node-positive or high-risk node-negative breast cancer, the addition of regional nodal irradiation to whole-breast irradiation did not improve overall survival but reduced the rate of breast-cancer recurrence. (Funded by the Canadian Cancer Society Research Institute and others; MA.20 ClinicalTrials.gov number,NCT00005957.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1415340?query=featured_home

JAMA - "Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes"

"Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes"

"Conclusions and Relevance  Pioglitazone use was not associated with a statistically significant increased risk of bladder cancer, although an increased risk, as previously observed, could not be excluded. The increased prostate and pancreatic cancer risks associated with ever use of pioglitazone merit further investigation to assess whether they are causal or are due to chance, residual confounding, or reverse causality."

https://jama.jamanetwork.com/article.aspx?articleid=2397834

Weekly Guideline - 2015 IOM "Strategies to Improve Cardiac Arrest Survival: A Time to Act"

http://iom.nationalacademies.org/Reports/2015/Strategies-to-Improve-Cardiac-Arrest-Survival.aspx

CIRC - "Pregnancy in Women With a Mechanical Heart Valve"

"Pregnancy in Women With a Mechanical Heart Valve"

"Conclusions—Women with an MHV have only a 58% chance of experiencing an uncomplicated pregnancy with a live birth. The markedly increased mortality and morbidity warrant extensive prepregnancy counseling and centralization of care."

http://circ.ahajournals.org/content/132/2/132.abstract

BMJ - "Real world effectiveness of primary implantable cardioverter defibrillators"

"Real world effectiveness of primary implantable cardioverter defibrillators implanted during hospital admissions for exacerbation of heart failure or other acute co-morbidities: cohort study of older patients with heart failure"

"Conclusion After adjustment for healthy candidate bias and confounding, the benefits of primary ICD therapy seen in pivotal trials were not apparent in patients aged 66 or over who received ICDs during a hospital admission for exacerbation of heart failure or other acute co-morbidities. Future research is warranted to further identify subgroups of elderly patients who are more likely to benefit from ICDs. Recognition of those patients whose dominant risk factors are from decompensated heart failure and non-cardiac co-morbidities will allow better focus on ICDs in those patients for whom the device offers the most benefit and provides meaningful prolonging of life."

http://www.bmj.com/content/351/bmj.h3529 

NEJM - "Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR"

"Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR"

"CONCLUSIONS

These data show that lumacaftor in combination with ivacaftor provided a benefit for patients with cystic fibrosis homozygous for the Phe508del CFTR mutation. (Funded by Vertex Pharmaceuticals and others; TRAFFIC and TRANSPORT ClinicalTrials.gov numbers,NCT01807923 and NCT01807949.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1409547?query=featured_home

JAMA - "Guideline-Based Statin Eligibility, Coronary Artery Calcification, and Cardiovascular Events"

"Guideline-Based Statin Eligibility, Coronary Artery Calcification, and Cardiovascular Events"

"Conclusions and Relevance  In this community-based primary prevention cohort, the ACC/AHA guidelines for determining statin eligibility, compared with the ATP III, were associated with greater accuracy and efficiency in identifying increased risk of incident CVD and subclinical coronary artery disease, particularly in intermediate-risk participants." 

https://jama.jamanetwork.com/article.aspx?articleid=2396478

Weekly Guideline - "2015 AHA/ASA Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment"

http://stroke.ahajournals.org/content/early/2015/06/26/STR.0000000000000074

CIRC - "Mass Screening for Untreated Atrial Fibrillation The STROKESTOP Study"

"Mass Screening for Untreated Atrial Fibrillation The STROKESTOP Study"

"Conclusions—Mass screening for AF in a 75- to 76-year-old population identifies a significant proportion of participants with untreated AF. Initiation of stroke prophylactic treatment was highly successful in individuals with newly diagnosed AF."

http://circ.ahajournals.org/content/131/25/2176.abstract

BMJ - "Risk of recurrent stillbirth: systematic review and meta-analysis"

"Risk of recurrent stillbirth: systematic review and meta-analysis"

"Conclusions The risk of stillbirth in subsequent pregnancies is higher in women who experience a stillbirth in their first pregnancy. This increased risk remained after adjusted analysis. Evidence surrounding the recurrence risk of unexplained stillbirth remains controversial.?"
http://www.bmj.com/content/350/bmj.h3080

NEJM - "A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management"

"A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management"

"CONCLUSIONS

In this study, 3.0 mg of liraglutide, as an adjunct to diet and exercise, was associated with reduced body weight and improved metabolic control. (Funded by Novo Nordisk; SCALE Obesity and Prediabetes NN8022-1839 ClinicalTrials.gov number, NCT01272219.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1411892?query=featured_home 

JAMA - "Use of Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction and Risk of Malignant Melanoma"

 "Use of Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction and Risk of Malignant Melanoma"

"Conclusions and Relevance  In a Swedish cohort of men, the use of PDE5 inhibitors was associated with a modest but statistically significant increased risk of malignant melanoma. However, the pattern of association (eg, the lack of association with multiple filled prescriptions) raises questions about whether this association is causal." 

http://jama.jamanetwork.com/article.aspx?articleid=2338254

Weekly Guideline - 2011 ASE "American Society of Echocardiography Clinical Recommendations for Multimodality Cardiovascular Imaging of Patients with Hypertrophic Cardiomyopathy"

http://www.asecho.org/wordpress/wp-content/uploads/2013/05/Multimodality-CV-Imaging-of-Patient-w-Hypertrophic-Cardiomyopathy.pdf

CIRC - B-Blockers and Mortality After CABG

"Efficacy of Long-Term β-Blocker Therapy for Secondary Prevention of Long-Term Outcomes After Coronary Artery Bypass Grafting Surgery"

"Conclusions—In patients with or without previous MI undergoing CABG, the consistent use of β-blockers was associated with a lower risk of long-term mortality and adverse cardiovascular events. Strategies should be developed to understand and improve discharge prescription of β-blockers and long-term patient adherence."

http://circ.ahajournals.org/content/131/25/2194.full

BMJ - "Use and risks of surgical mesh for pelvic organ prolapse surgery in women in New York state: population based cohort study"

"Use and risks of surgical mesh for pelvic organ prolapse surgery in women in New York state: population based cohort study"

"Conclusions Despite multiple warnings released by the US Food and Drug Administration since 2008, use of mesh in pelvic organ prolapse surgery continues to grow. In this statewide comprehensive study, mesh procedures were associated with an increased risk of reinterventions within one year and urinary retention after surgery."

http://www.bmj.com/content/350/bmj.h2685