NEJM - BP Control in DM-2 (ADVANCE)

 "Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes"

"CONCLUSIONS

The benefits with respect to mortality that had been observed among patients originally assigned to blood-pressure–lowering therapy were attenuated but still evident at the end of follow-up. There was no evidence that intensive glucose control during the trial led to long-term benefits with respect to mortality or macrovascular events. (Funded by the National Health and Medical Research Council of Australia and others; ADVANCE-ON ClinicalTrials.gov number, NCT00949286.)"    

http://www.nejm.org/doi/full/10.1056/NEJMoa1407963?query=featured_home

JAMA - Antenatal MgSo4 in Preterm

"School-age Outcomes of Very Preterm Infants After Antenatal Treatment With Magnesium Sulfate vs Placebo"

"Conclusions and Relevance  Magnesium sulfate given to pregnant women at imminent risk of birth before 30 weeks’ gestation was not associated with neurological, cognitive, behavioral, growth, or functional outcomes in their children at school age, although a mortality advantage cannot be excluded. The lack of long-term benefit requires confirmation in additional studies."  
http://jama.jamanetwork.com/article.aspx?articleid=1904828

Weekly Guideline - e Cigarettes

"Electronic Cigarettes: A Policy Statement From the American Heart Association"

http://circ.ahajournals.org/content/early/2014/08/22/CIR.0000000000000107

CIRC - ICD Infections

"Rates of and Factors Associated With Infection in 200 909 Medicare Implantable Cardioverter-Defibrillator Implants"

"Conclusions—Patients who developed an ICD infection were more likely to have had peri-ICD implant complications requiring early reintervention, previous valve surgery, device replacement for reasons other than battery depletion, and increased comorbidity burden. Efforts should be made to carefully consider when to reenter the pocket at any time other than battery replacement."   

http://circ.ahajournals.org/content/130/13/1037.abstract

BMJ - Alzheimer's & Benzodiazepines

"Benzodiazepine use and risk of Alzheimer’s disease: case-control study"

"Conclusion
Benzodiazepine use is associated with an increased risk of Alzheimer’s disease. The stronger association observed for long term exposures reinforces the suspicion of a possible direct association, even if benzodiazepine use might also be an early marker of a condition associated with an increased risk of dementia. Unwarranted long term use of these drugs should be considered as a public health concern."  

http://www.bmj.com/content/349/bmj.g5205

NEJM - Ivabradine in Stable CAD

"Ivabradine in Stable Coronary Artery Disease without Clinical Heart Failure"

"CONCLUSIONS

Among patients who had stable coronary artery disease without clinical heart failure, the addition of ivabradine to standard background therapy to reduce the heart rate did not improve outcomes. (Funded by Servier; SIGNIFY Current Controlled Trials number,ISRCTN61576291.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1406430

JAMA - B-Agonists and Inhaled Corticosteroids in COPD

"Combination Long-Acting β-Agonists and Inhaled Corticosteroids Compared With Long-Acting β-Agonists Alone in Older Adults With Chronic Obstructive Pulmonary Disease"

"Conclusions and Relevance  Among older adults with COPD, particularly those with asthma and those not receiving a long-acting anticholinergic medication, newly prescribed LABA and inhaled corticosteroid combination therapy, compared with newly prescribed LABAs alone, was associated with a significantly lower risk of the composite outcome of death or COPD hospitalization."  

http://jama.jamanetwork.com/article.aspx?articleid=1904829

Weekly Guideline - Perioperative Cardiovascular Evaluation:

"Clinical Practice Guidelines on Perioperative Cardiovascular Evaluation: Collaborative Efforts Among the ACC, AHA, and ESC"

http://content.onlinejacc.org/article.aspx?articleid=1893782

JACC - CABG vs PCI in DM

"Long-Term Outcome of PCI Versus CABG in Insulin and Non–Insulin-Treated Diabetic Patients"

"Conclusions  In patients with diabetes and multivessel coronary artery disease, the rate of major adverse cardiovascular events (death, MI, or stroke) is higher in patients treated with insulin than in those not treated with insulin. Furthermore, we did not detect a significant difference in the magnitude of PCI versus CABG treatment effect for patients treated with insulin and those not treated with insulin. (Comparison of Two Treatments for Multivessel Coronary Artery Disease in Individuals With Diabetes [FREEDOM]; NCT00086450)."
http://content.onlinejacc.org/article.aspx?articleID=1905458

BMJ - Breast CA Screening

"Effect of implementation of the mass breast cancer screening programme in older women in the Netherlands: population based study"    

"Conclusions The extension of the upper age limit to 75 years has only led to a small decrease in incidence of advanced stage breast cancer, while that of early stage tumours has strongly increased."  
http://www.bmj.com/content/349/bmj.g5410

NEJM - ALL

"Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia"

"CONCLUSIONS

Ph-like ALL was found to be characterized by a range of genomic alterations that activate a limited number of signaling pathways, all of which may be amenable to inhibition with approved tyrosine kinase inhibitors. Trials identifying Ph-like ALL are needed to assess whether adding tyrosine kinase inhibitors to current therapy will improve the survival of patients with this type of leukemia. (Funded by the American Lebanese Syrian Associated Charities and others."

http://www.nejm.org/doi/full/10.1056/NEJMoa1403088?query=featured_home

JAMA - Darapladibin ACS

"Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome"

"Conclusions and Relevance  In patients who experienced an ACS event, direct inhibition of Lp-PLA2with darapladib added to optimal medical therapy and initiated within 30 days of hospitalization did not reduce the risk of major coronary events."


http://jama.jamanetwork.com/article.aspx?articleid=1900827

Weekly Guideline Update - Beta Blockade in Noncardiac Surgery

"Perioperative : A Systematic Review for the 2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery"


http://content.onlinejacc.org/article.aspx?articleid=1893783

CIRC - WPW

"Wolff-Parkinson-White Syndrome in the Era of Catheter Ablation Insights From a Registry Study of 2169 Patients"

"Conclusions—The prognosis of the Wolff-Parkinson-White syndrome essentially depends on intrinsic electrophysiological properties of AP rather than on symptoms. RFA performed during the same procedure after electrophysiological testing is of benefit in improving the long-term outcomes."  

http://circ.ahajournals.org/content/130/10/811.abstract 

BMJ - Antiepileptics in Pregnancy

"Use of antiepileptic drugs during pregnancy and risk of spontaneous abortion and stillbirth: population based cohort study"

"Conclusion Among women with epilepsy and when analysing the risk in antiepileptic drug discordant pregnancies in the same woman, we found no overall association between the use of antiepileptic drugs during pregnancy and spontaneous abortions. Therefore unmeasured confounding may explain the slight increased risk for spontaneous abortion with any antiepileptic drug use (among women both with and without epilepsy). We found no association between antiepileptic drug use during pregnancy and stillbirth, but the statistical precision was low."
http://www.bmj.com/content/349/bmj.g5159

NEJM - Influenza Vaccination of Pregnant Women

"Influenza Vaccination of Pregnant Women and Protection of Their Infants"

"CONCLUSIONS

Influenza vaccine was immunogenic in HIV-uninfected and HIV-infected pregnant women and provided partial protection against confirmed influenza in both groups of women and in infants who were not exposed to HIV. (Funded by the Bill and Melinda Gates Foundation and others; ClinicalTrials.gov numbers, NCT01306669 andNCT01306682.)"  

http://www.nejm.org/doi/full/10.1056/NEJMoa1401480 

JAMA - Weight Loss with Named Diet Programs

"Comparison of Weight Loss Among Named Diet Programs in Overweight and Obese Adults A Meta-analysis"

"Conclusions and Relevance  Significant weight loss was observed with any low-carbohydrate or low-fat diet. Weight loss differences between individual named diets were small. This supports the practice of recommending any diet that a patient will adhere to in order to lose weight."  

http://jama.jamanetwork.com/article.aspx?articleid=1900510

Weekly Guideline - Worksite Health Screening

"AHA Policy Statement The Role of Worksite Health Screening A Policy Statement From the American Heart Association"

http://circ.ahajournals.org/content/130/8/719.full

JACC - "Acute Kidney Injury After CABG Versus PCI"

"Acute Kidney Injury After CABG Versus PCI"

"Conclusions  AKI is common after multivessel coronary revascularization and is more likely after CABG than after PCI. The risk for AKI should be considered when choosing a coronary revascularization strategy, and ways to prevent AKI after coronary revascularization are needed."

http://content.onlinejacc.org/article.aspx?articleID=1900736

BMJ - Commuting and BMI

"Associations between active commuting, body fat, and body mass index: population based, cross sectional study in the United Kingdom"

"Conclusions Men and women who commuted to work by active and public modes of transport had significantly lower BMI and percentage body fat than their counterparts who used private transport. These associations were not attenuated by adjustment for a range of hypothesised confounding factors."


http://www.bmj.com/content/349/bmj.g4887

NEJM - Angiotensin–Neprilysin Inhibition

"Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure"

"CONCLUSIONS

LCZ696 was superior to enalapril in reducing the risks of death and of hospitalization for heart failure. (Funded by Novartis; PARADIGM-HF ClinicalTrials.gov number, NCT01035255.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1409077?query=featured_home

JAMA - Colchicine

"Colchicine for Prevention of Postpericardiotomy Syndrome and Postoperative Atrial Fibrillation The COPPS-2 Randomized Clinical Trial"

"Conclusions and Relevance  Among patients undergoing cardiac surgery, perioperative use of colchicine compared with placebo reduced the incidence of postpericardiotomy syndrome but not of postoperative AF or postoperative pericardial/pleural effusion. The increased risk of gastrointestinal adverse effects reduced the potential benefits of colchicine in this setting."

http://jama.jamanetwork.com/article.aspx?articleid=1900482