"Association between cardiovascular events and sodium-containing effervescent, dispersible, and soluble drugs: nested case-control study"
BMJ
http://www.bmj.com/content/347/bmj.f6954
"Conclusions Exposure to sodium-containing formulations of effervescent, dispersible, and soluble medicines was associated with significantly increased odds of adverse cardiovascular events compared with standard formulations of those same drugs. Sodium-containing formulations should be prescribed with caution only if the perceived benefits outweigh these risks."