"Interpretation
Standard-dose and high-dose biological drugs (with or without traditional DMARDs) are associated with an increase in serious infections in rheumatoid arthritis compared with traditional DMARDs, although low-dose biological drugs are not. Clinicians should discuss the balance between benefit and harm with the individual patient before starting biological treatment for rheumatoid arthritis."
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61704-9/abstract
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