"Time to Treatment With Intravenous Tissue Plasminogen Activator and Outcome From Acute Ischemic Stroke"
JAMA Jun 19
http://jama.jamanetwork.com/article.aspx?articleid=1697967 
"Conclusions and Relevance  In a registry representing US clinical practice, earlier thrombolytic treatment was associated with reduced mortality and symptomatic intracranial hemorrhage, and higher rates of independent ambulation at discharge and discharge to home following acute ischemic stroke. These findings support intensive efforts to accelerate hospital presentation and thrombolytic treatment in patients with stroke."