"Targeted versus Universal Decolonization to Prevent ICU Infection"
NEJM May 29
http://www.nejm.org/doi/full/10.1056/NEJMoa1207290 
"CONCLUSIONS

In routine ICU practice, universal decolonization was more effective than targeted decolonization or screening and isolation in reducing rates of MRSA clinical isolates and bloodstream infection from any pathogen. (Funded by the Agency for Healthcare Research and the Centers for Disease Control and Prevention; REDUCE MRSA ClinicalTrials.gov number, NCT00980980.)"