"Aspirin Use and Risk of Colorectal Cancer According to BRAF Mutation Status" 
JAMA Jun 26
http://jama.jamanetwork.com/article.aspx?articleid=1700495 
"Conclusions and Relevance  Regular aspirin use was associated with lower risk of BRAF–wild-type colorectal cancer but not with BRAF-mutated cancer risk. These findings suggest that BRAF-mutant colon tumor cells may be less sensitive to the effect of aspirin. Given the modest absolute risk difference, further investigations are necessary to determine clinical implications of our findings."

"Screening for Hepatitis C Virus Infection in Adults: U.S. Preventive Services Task Force Recommendation Statement"    
Annals Jun 25  
http://annals.org/article.aspx?articleid=1700383   
"Recommendation: The USPSTF recommends screening for HCV infection in persons at high risk for infection. The USPSTF also recommends offering 1-time screening for HCV infection to adults born between 1945 and 1965. (B recommendation)"

"Changes in Plaque Lipid Content After Short-Term Intensive Versus Standard Statin Therapy"  
JACC July 2013
http://content.onlinejacc.org/article.aspx?articleid=1686313 
"Conclusions  Short-term intensive statin therapy may reduce lipid content in obstructive lesions. These hypothesis-generating findings warrant confirmation in larger studies with longer follow-up."  

"Sex Differences in the Effectiveness of Early Coronary Computed Tomographic Angiography Compared With Standard Emergency Department Evaluation for Acute Chest Pain"   
Circ May/Jun 2013
http://circ.ahajournals.org/content/127/25/2494.abstract
"Conclusions—This trial provides data supporting an early CCTA strategy as an attractive option in women presenting to the ED with symptoms suggestive of acute coronary syndrome. The findings may be explained by lower CAD prevalence and severity in women than men."

"Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial"
Lancet Jun 21
http://www.lancet.com/journals/laneur/article/PIIS1474-4422(13)70130-3/fulltext 
"Interpretation

IST-3 provides evidence that thrombolysis with intravenous alteplase for acute ischaemic stroke does not affect survival, but does lead to statistically significant, clinically relevant improvements in functional outcome and health-related quality of life that are sustained for at least 18 months."

"Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis" 
BMJ Jun 2013
http://www.bmj.com/content/346/bmj.f3443
"Conclusions Daily prenatal use of iron substantially improved birth weight in a linear dose-response fashion, probably leading to a reduction in risk of low birth weight. An improvement in prenatal mean haemoglobin concentration linearly increased birth weight."

"Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus" 
NEJM Jun 19
http://www.nejm.org/doi/full/10.1056/NEJMoa1306742?query=featured_home
"CONCLUSIONS

Person-to-person transmission of MERS-CoV can occur in health care settings and may be associated with considerable morbidity. Surveillance and infection-control measures are critical to a global public health response"

"Time to Treatment With Intravenous Tissue Plasminogen Activator and Outcome From Acute Ischemic Stroke"
JAMA Jun 19
http://jama.jamanetwork.com/article.aspx?articleid=1697967 
"Conclusions and Relevance  In a registry representing US clinical practice, earlier thrombolytic treatment was associated with reduced mortality and symptomatic intracranial hemorrhage, and higher rates of independent ambulation at discharge and discharge to home following acute ischemic stroke. These findings support intensive efforts to accelerate hospital presentation and thrombolytic treatment in patients with stroke."

"Observation Versus Initial Treatment for Men With Localized, Low-Risk Prostate Cancer: A Cost-Effectiveness Analysis"
Annals Jun 18
http://annals.org/article.aspx?articleid=1696642
"Conclusion: Among these men, observation is more effective and costs less than initial treatment, and WW is most effective and least expensive under a wide range of clinical scenarios.

Primary Funding Source: National Cancer Institute, U.S. Department of Defense, Prostate Cancer Foundation, and Institute for Clinical and Economic Review."

"Comparison of Transcatheter and Surgical Aortic Valve Replacement in Severe Aortic Stenosis"
JACC Jun 2013
http://content.onlinejacc.org/article.aspx?articleid=1685119 
"Conclusions  Patients randomized to either SAVR or TAVR experience enduring, significant reductions in transaortic gradients and increase in EOA. Compared with SAVR, TAVR patients had higher indexed EOA, lower prosthesis-patient mismatch, and more aortic regurgitation. Univariate predictors of death for the TAVR and SAVR groups differed and might allow future refinement in patient selection. "

"Ambulatory Blood Pressure Changes after Renal Sympathetic Denervation in Patients with Resistant Hypertension"
Circ Jun 18
http://circ.ahajournals.org/content/early/2013/06/18/CIRCULATIONAHA.112.000949.abstract
"Conclusions—RDN reduced office BP and improved relevant aspects of ABPM, commonly linked to high cardiovascular risk, in patients with true-treatment resistant hypertension while it only affected office BP in pseudo-resistant hypertension."

"Anti-acid treatment and disease progression in idiopathic pulmonary fibrosis: an analysis of data from three randomised controlled trials"
Lancet Jun 14
http://www.lancet.com/journals/lanres/article/PIIS2213-2600(13)70105-X/fulltext 
"Interpretation

Anti-acid treatment could be beneficial in patients with IPF, and abnormal acid gastro-oesophageal reflux seems to contribute to disease progression. Controlled clinical trials of anti-acid treatments are now needed."

"Effectiveness of a bundled intervention of decolonization and prophylaxis to decrease Gram positive surgical site infections after cardiac or orthopedic surgery: systematic review and meta-analysis" 
BMJ Jun 13
http://www.bmj.com/content/346/bmj.f2743 
"Conclusions Surgical programs that implement a bundled intervention including both nasal decolonization and glycopeptide prophylaxis for MRSA carriers may decrease rates of surgical site infections caused by S aureus or other Gram positive bacteria."

"Racemic Adrenaline and Inhalation Strategies in Acute Bronchiolitis" 
NEJM Jun 13
http://www.nejm.org/doi/full/10.1056/NEJMoa1301839 
"CONCLUSIONS

In the treatment of acute bronchiolitis in infants, inhaled racemic adrenaline is not more effective than inhaled saline. However, the strategy of inhalation on demand appears to be superior to that of inhalation on a fixed schedule. (Funded by Medicines for Children; ClinicalTrials.gov number, NCT00817466; EudraCT number, 2009-012667-34.)"

"Maternal Obesity and Risk of Preterm Delivery" 
JAMA Jun 12
http://jama.jamanetwork.com/article.aspx?articleid=1696099 
"Conclusions and Relevance  In Sweden, maternal overweight and obesity during pregnancy were associated with increased risks of preterm delivery, especially extremely preterm delivery. These associations should be assessed in other populations."

"Clinical Outcome Following Stringent Discontinuation of Dual Antiplatelet Therapy After 12 Months in Real-World Patients Treated With Second-Generation Zotarolimus-Eluting Resolute and Everolimus-Eluting Xience V Stents" 
JACC Jun 2013
http://content.onlinejacc.org/article.aspx?articleid=1696810
"Conclusions  After 2 years of follow-up and stringent discontinuation of DAPT beyond 12 months, Resolute ZES and Xience V EES showed similar results in terms of safety and efficacy for treating patients with a majority of complex lesions and off-label indications for drug-eluting stents. "

"Adoption of Radial Access and Comparison of Outcomes to Femoral Access in Percutaneous Coronary Intervention"
Circ Jun 11
http://circ.ahajournals.org/content/127/23/2295.abstract
"Conclusions—There has been increasing adoption of r-PCI in the United States. Transradial PCI now accounts for 1 of 6 PCIs performed in contemporary clinical practice. In comparison with traditional femoral access, transradial PCI is associated with lower vascular and bleeding complication rates."

"Boceprevir versus placebo with pegylated interferon alfa-2b and ribavirin for treatment of hepatitis C virus genotype 1 in patients with HIV: a randomised, double-blind, controlled phase 2 trial" 
Lancet Jun 12
http://www.lancet.com/journals/laninf/article/PIIS1473-3099(13)70149-X/fulltext
"Interpretation

Boceprevir in combination with peginterferon—ribavirin could be an important therapeutic option for patients with HCV and HIV.
FundingMerck."

"Shared care obesity management in 3-10 year old children: 12 month outcomes of HopSCOTCH randomised trial"
BMJ Jun 10
http://www.bmj.com/content/346/bmj.f3092
"Conclusions Although feasible, not harmful, and highly rated by both families and general practitioners, the shared care model of primary and tertiary care management did not lead to better body mass index or other outcomes for the intervention group compared with the control group. Improvements in body mass index in both groups highlight the value of untreated controls when determining efficacy."

"Prone Positioning in Severe Acute Respiratory Distress Syndrome"
NEJM Jun 6
http://www.nejm.org/doi/full/10.1056/NEJMoa1214103
"CONCLUSIONS

In patients with severe ARDS, early application of prolonged prone-positioning sessions significantly decreased 28-day and 90-day mortality. (Funded by the Programme Hospitalier de Recherche Clinique National 2006 and 2010 of the French Ministry of Health; PROSEVA ClinicalTrials.gov number, NCT00527813.)"

"Short-term vs Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

The REDUCE Randomized Clinical Trial

JAMA May 21
http://jama.jamanetwork.com/article.aspx?articleid=1688035 
"Conclusions and Relevance  In patients presenting to the emergency department with acute exacerbations of COPD, 5-day treatment with systemic glucocorticoids was noninferior to 14-day treatment with regard to reexacerbation within 6 months of follow-up but significantly reduced glucocorticoid exposure. These findings support the use of a 5-day glucocorticoid treatment in acute exacerbations of COPD."

"Should Bilateral Internal Thoracic Artery Grafting Be Used in Elderly Patients Undergoing Coronary Artery Bypass Grafting?"
Circ Jun 4
http://circ.ahajournals.org/content/127/22/2186.abstract
"Conclusions—Bilateral internal thoracic artery grafting should be considered in patients >65 years of age because of the significant survival benefit obtained with this surgical technique with no additional risk of sternal wound infection related to age."

"2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary"
JACC Jun 2013
http://content.onlinejacc.org/article.aspx?articleid=1695826

"Day of week of procedure and 30 day mortality for elective surgery: retrospective analysis of hospital episode statistics"
BMJ May 28
http://www.bmj.com/content/346/bmj.f2424 
"Conclusions The study suggests a higher risk of death for patients who have elective surgical procedures carried out later in the working week and at the weekend."

"Summary of evidence-based guideline: Periprocedural management of antithrombotic medications in patients with ischemic cerebrovascular diseaseReport of the Guideline Development Subcommittee of the American Academy of Neurology"
Neurology May 28
http://www.neurology.org/content/80/22/2065.full
"Objective: To assess evidence regarding periprocedural management of antithrombotic drugs in patients with ischemic cerebrovascular disease. The complete guideline on which this summary is based is available as an online data supplement to this article."

"Targeted versus Universal Decolonization to Prevent ICU Infection"
NEJM May 29
http://www.nejm.org/doi/full/10.1056/NEJMoa1207290 
"CONCLUSIONS

In routine ICU practice, universal decolonization was more effective than targeted decolonization or screening and isolation in reducing rates of MRSA clinical isolates and bloodstream infection from any pathogen. (Funded by the Agency for Healthcare Research and the Centers for Disease Control and Prevention; REDUCE MRSA ClinicalTrials.gov number, NCT00980980.)"

"Effect of Escitalopram on Mental Stress–Induced Myocardial Ischemia
Results of the REMIT Trial"  
JAMA May 22
http://jama.jamanetwork.com/article.aspx?articleid=1690699
"Conclusions and Relevance  Among patients with stable coronary heart disease and baseline MSIMI, 6 weeks of escitalopram, compared with placebo, resulted in a lower rate of MSIMI. There was no statistically significant difference in exercise-induced ischemia. Replication of these results in multicenter settings and investigations of other medications for reducing MSIMI are needed."

"Cardiovascular Safety of Inhaled Long-Acting Bronchodilators in Individuals With Chronic Obstructive Pulmonary Disease" 
JAMA IM May 20
http://archinte.jamanetwork.com/article.aspx?articleid=1689974
"Conclusions and Relevance  Among older individuals with COPD, new use of long-acting β-agonists and anticholinergics is associated with similar increased risks of cardiovascular events. Close monitoring of COPD patients requiring long-acting bronchodilators is needed regardless of drug class."

"Effect of Age, Tumor Risk, and Comorbidity on Competing Risks for Survival in a U.S. Population–Based Cohort of Men With Prostate Cancer"  
Annals IM May 21
http://annals.org/article.aspx?articleid=1688109
"Conclusion: Older men with multiple major comorbid conditions are at high risk for other-cause mortality within 10 years of diagnosis and should consider this information when deciding between conservative management and aggressive treatment for low- or intermediate-risk prostate cancer."

"A Novel Tool for Reliable and Accurate Prediction of Renal Complications in Patients Undergoing Percutaneous Coronary Intervention"  
JACC June 2013
http://content.onlinejacc.org/article.aspx?articleid=1693151 
"Conclusions  The risk of CIN and NRD among patients undergoing PCI can be reliably calculated using a novel easy-to-use computational tool (https://bmc2.org/calculators/cin). This risk prediction algorithm may prove useful for both bedside clinical decision making and risk adjustment for assessment of quality"