"Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease"
"Conclusions and Relevance Among adult patients with refractory Crohn disease not amenable to surgery who had impaired quality of life, HSCT, compared with conventional therapy, did not result in a statistically significant improvement in sustained disease remission at 1 year and was associated with significant toxicity. These findings do not support the widespread use of HSCT for patients with refractory Crohn disease."
http://jama.jamanetwork.com/article.aspx?articleid=2475462
"Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection" "Conclusions and Relevance Among adults with recurrent or refractory CDI, the use of frozen compared with fresh FMT did not result in worse proportion of clinical resolution of diarrhea. Given the potential advantages of providing frozen FMT, its use is a reasonable option in this setting."
http://jama.jamanetwork.com/article.aspx?articleid=2481003
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NEJM
"Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection"
"CONCLUSIONS
Once-daily sofosbuvir–velpatasvir for 12 weeks provided high rates of sustained virologic response among both previously treated and untreated patients infected with HCV genotype 1, 2, 4, 5, or 6, including those with compensated cirrhosis. (Funded by Gilead Sciences; ClinicalTrials.gov number, NCT02201940.)" http://www.nejm.org/doi/full/10.1056/NEJMoa1512610?query=featured_home
REVIEW:
"Relationship between Nonmedical Prescription-Opioid Use and Heroin Use"
"The nonmedical use of prescription opioids is a major public health issue in the United States, both because of the overall high prevalence and because of marked increases in associated morbidity and mortality.1 In 2014, a total of 10.3 million persons reported using prescription opioids nonmedically (i.e., using medications that were not prescribed for them or were taken only for the experience or feeling that they caused).2 Emergency department visits involving misuse or abuse of prescription opioids increased 153% between 2004 and 2011, and admissions to substance-abuse treatment programs linked to prescription opioids more than quadrupled between 2002 and 2012.3,4Most troubling, between 2000 and 2014 the rates of death from prescription-opioid overdose nearly quadrupled (from 1.5 to 5.9 deaths per 100,000 persons) (Figure 1)."
http://www.nejm.org/doi/full/10.1056/NEJMra1508490?query=featured_home
REVIEW:
"Relationship between Nonmedical Prescription-Opioid Use and Heroin Use"
"The nonmedical use of prescription opioids is a major public health issue in the United States, both because of the overall high prevalence and because of marked increases in associated morbidity and mortality.1 In 2014, a total of 10.3 million persons reported using prescription opioids nonmedically (i.e., using medications that were not prescribed for them or were taken only for the experience or feeling that they caused).2 Emergency department visits involving misuse or abuse of prescription opioids increased 153% between 2004 and 2011, and admissions to substance-abuse treatment programs linked to prescription opioids more than quadrupled between 2002 and 2012.3,4Most troubling, between 2000 and 2014 the rates of death from prescription-opioid overdose nearly quadrupled (from 1.5 to 5.9 deaths per 100,000 persons) (Figure 1)."
http://www.nejm.org/doi/full/10.1056/NEJMra1508490?query=featured_home
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BMJ / Lancet
BMJ: "Nosocomial transmission of avian influenza A (H7N9) virus in China: epidemiological investigation"
"What this study adds
Nosocomial H7N9 transmission might be possible between two unrelated individuals. Surveillance on patients with influenza-like illness in hospitals as well as chickens in live poultry markets should be enhanced to monitor transmissibility and pathogenicity of the virus."
http://www.bmj.com/content/351/bmj.h5765
Lancet: "Continued versus discontinued cannabis use in patients with psychosis: a systematic review and meta-analysis"
"Interpretation Continued cannabis use after onset of psychosis predicts adverse outcome, including higher relapse rates, longer hospital admissions, and more severe positive symptoms than for individuals who discontinue cannabis use and those who are non-users. These findings point to reductions in cannabis use as a crucial interventional target to improve outcome in patients with psychosis." http://lancet.com/journals/lanpsy/article/PIIS2215-0366(15)00363-6/abstract
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CIRC
"Hypertrophic Cardiomyopathy in Children, Adolescents, and Young Adults Associated With Low Cardiovascular Mortality With Contemporary Management Strategies"
"Conclusions—In a large hospital-based cohort of young HCM patients, representing an age group considered at greatest risk, low mortality rates can be achieved with the application of contemporary cardiovascular treatment strategies, largely because of reliable identification of high-risk patients who benefited from implantable cardioverter-defibrillators for sudden death prevention, thereby creating the opportunity for extended longevity and good quality of life."
http://circ.ahajournals.org/content/133/1/62.abstract
"Physical Activity and Risk of Coronary Heart Disease and Stroke in Older Adults The Cardiovascular Health Study"
"Conclusions—These data provide empirical evidence supporting PA recommendations, in particular, walking, to reduce the incidence of CVD among older adults." http://circ.ahajournals.org/content/133/2/147.abstract
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