NEJM - High Flow O2 in Acute Respiratory Failure

"High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure"

"CONCLUSIONS

In patients with nonhypercapnic acute hypoxemic respiratory failure, treatment with high-flow oxygen, standard oxygen, or noninvasive ventilation did not result in significantly different intubation rates. There was a significant difference in favor of high-flow oxygen in 90-day mortality. (Funded by the Programme Hospitalier de Recherche Clinique Interrégional 2010 of the French Ministry of Health; FLORALI ClinicalTrials.gov number, NCT01320384.)"  

http://www.nejm.org/doi/full/10.1056/NEJMoa1503326?query=featured_home