"Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism"
NEJM Oct 10
http://www.nejm.org/doi/full/10.1056/NEJMoa1306638?query=featured_home
"CONCLUSIONS 

Edoxaban administered once daily after initial treatment with heparin was noninferior to high-quality standard therapy and caused significantly less bleeding in a broad spectrum of patients with venous thromboembolism, including those with severe pulmonary embolism."