NEJM - "Clindamycin versus Trimethoprim–Sulfamethoxazole for Uncomplicated Skin Infections"

"Clindamycin versus Trimethoprim–Sulfamethoxazole for Uncomplicated Skin Infections"

"CONCLUSIONS

We found no significant difference between clindamycin and TMP-SMX, with respect to either efficacy or side-effect profile, for the treatment of uncomplicated skin infections, including both cellulitis and abscesses. (Funded by the National Institute of Allergy and Infectious Diseases and the National Center for Advancing Translational Sciences, National Institutes of Health; ClinicalTrials.gov number, NCT00730028.)" 

http://www.nejm.org/doi/full/10.1056/NEJMoa1403789 

JAMA -

"Antiplatelet Therapy Duration Following Bare Metal or Drug-Eluting Coronary Stents The Dual Antiplatelet Therapy Randomized Clinical Trial"

"Conclusions and Relevance  Among patients undergoing coronary stent placement with BMS and who tolerated 12 months of thienopyridine, continuing thienopyridine for an additional 18 months compared with placebo did not result in statistically significant differences in rates of stent thrombosis, MACCE, or moderate or severe bleeding. However, the BMS subset may have been underpowered to identify such differences, and further trials are suggested."   

https://jama.jamanetwork.com/article.aspx?articleid=2203799

Weekly Guideline 2014 ACG Lynch Syndrome

"Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer"

http://gi.org/guideline/guidelines-on-genetic-evaluation-and-management-of-lynch-syndrome-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer/

PDF:
http://gi.org/wp-content/uploads/2014/08/Giardiello_et_al_Lynch-Syndrome_Aug_2014.pdf

CIRC - "Antiandrogenic Therapy With Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction"

 "Antiandrogenic Therapy With Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction"

"Conclusions—Finasteride, which is currently used in patients to treat prostate disease, potently reverses pathological cardiac hypertrophy and dysfunction in mice and might be a therapeutic option for heart failure."

http://circ.ahajournals.org/content/131/12/1071.abstract   

Lancet - ENGAGE AF-TIMI 48 - Warfarin and Edoxaban

"Genetics and the clinical response to warfarin and edoxaban: findings from the randomised, double-blind ENGAGE AF-TIMI 48 trial"

"Interpretation

CYP2C9 and VKORC1 genotypes identify patients who are more likely to experience early bleeding with warfarin and who derive a greater early safety benefit from edoxaban compared with warfarin.   

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61994-2/abstract 

NEJM - "Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults"

"Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults"

"CONCLUSIONS

Among older adults, PCV13 was effective in preventing vaccine-type pneumococcal, bacteremic, and nonbacteremic community-acquired pneumonia and vaccine-type invasive pneumococcal disease but not in preventing community-acquired pneumonia from any cause. (Funded by Pfizer; CAPITA ClinicalTrials.gov number NCT00744263.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1408544?query=featured_home 

JAMA - "Effect of a Balloon-Expandable Intracranial Stent vs Medical Therapy on Risk of Stroke in Patients With Symptomatic Intracranial Stenosis The VISSIT Randomized Clinical Trial"

"Effect of a Balloon-Expandable Intracranial Stent vs Medical Therapy on Risk of Stroke in Patients With Symptomatic Intracranial Stenosis The VISSIT Randomized Clinical Trial"

"Conclusions and Relevance  Among patients with symptomatic intracranial arterial stenosis, the use of a balloon-expandable stent compared with medical therapy resulted in an increased 12-month risk of added stroke or TIA in the same territory, and increased 30-day risk of any stroke or TIA. These findings do not support the use of a balloon-expandable stent for patients with symptomatic intracranial arterial stenosis."


http://jama.jamanetwork.com/article.aspx?articleid=2208809