Weekly Guideline - 2014 AHA Postthrombotic Syndrome

"The Postthrombotic Syndrome: Evidence-Based Prevention, Diagnosis, and Treatment Strategies"

http://circ.ahajournals.org/content/130/18/1636

CIRC - Linoleic Acid and Risk of CHD

"Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies"

"Conclusions—In prospective observational studies, dietary LA intake is inversely associated with CHD risk in a dose–response manner. These data provide support for current recommendations to replace saturated fat with polyunsaturated fat for primary prevention of CHD."

http://circ.ahajournals.org/content/130/18/1568.abstract

BMJ - Thoracoscopic versus Open Lobectomy

"Long term survival with thoracoscopic versus open lobectomy: propensity matched comparative analysis using SEER-Medicare database"

"Conclusion This propensity matched analysis showed that patients undergoing thoracoscopic lobectomy had similar overall, cancer specific, and disease-free survival compared with patients undergoing thoracotomy lobectomy. Thoracoscopic techniques do not seem to compromise these measures of outcome after lobectomy."

http://www.bmj.com/content/349/bmj.g5575

NEJM - Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes

"Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes"

"CONCLUSIONS

The benefits with respect to mortality that had been observed among patients originally assigned to blood-pressure–lowering therapy were attenuated but still evident at the end of follow-up. There was no evidence that intensive glucose control during the trial led to long-term benefits with respect to mortality or macrovascular events. (Funded by the National Health and Medical Research Council of Australia and others; ADVANCE-ON ClinicalTrials.gov number, NCT00949286.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1407963 

JAMA - Vancomycin & Staphylococcus aureus Bloodstream Infections

"Association Between Vancomycin Minimum Inhibitory Concentration and Mortality Among Patients With Staphylococcus aureus Bloodstream Infections"

"Conclusions and Relevance  In this meta-analysis of SAB episodes, there were no statistically significant differences in the risk of death when comparing patients with S aureus exhibiting high-vancomycin MIC (≥1.5 mg/L) to those with low-vancomycin MIC (<1.5 mg/L), although the findings cannot definitely exclude an increased mortality risk. These findings should be considered when interpreting vancomycin susceptibility and in determining whether alternative antistaphylococcal agents are necessary for patients with SAB with elevated but susceptible vancomycin MIC values."

http://jama.jamanetwork.com/article.aspx?articleid=1913620

JACC - Fractional Flow Reserve

 "Prognostic Value of Fractional Flow Reserve"

"Conclusions  FFR demonstrates a continuous and independent relationship with subsequent outcomes, modulated by medical therapy versus revascularization. Lesions with lower FFR values receive larger absolute benefits from revascularization. Measurement of FFR immediately after stenting also shows an inverse gradient of risk, likely from residual diffuse disease. An FFR-guided revascularization strategy significantly reduces events and increases freedom from angina with fewer procedures than an anatomy-based strategy."

http://content.onlinejacc.org/article.aspx?articleID=1915294

BMJ - Industry Sponsorship Bias in Statin Trials

 "Industry sponsorship bias in research findings: a network meta-analysis of LDL cholesterol reduction in randomised trials of statins"

"Conclusions Our analysis shows that the findings obtained from industry sponsored statin trials seem similar in magnitude as those in non-industry sources. There are actual differences in the effectiveness of individual statins at various doses that explain previously observed discrepancies between industry and non-industry sponsored trials."


http://www.bmj.com/content/349/bmj.g5741