"Aspirin Use and Risk of Colorectal Cancer According to BRAF Mutation Status"
JAMA Jun 26
http://jama.jamanetwork.com/article.aspx?articleid=1700495
"Conclusions and Relevance Regular aspirin use was associated with lower risk of BRAF–wild-type colorectal cancer but not with BRAF-mutated cancer risk. These findings suggest that BRAF-mutant colon tumor cells may be less sensitive to the effect of aspirin. Given the modest absolute risk difference, further investigations are necessary to determine clinical implications of our findings."
Sunday, June 30, 2013
Saturday, June 29, 2013
"Screening for Hepatitis C Virus Infection in Adults: U.S. Preventive Services Task Force Recommendation Statement"
Annals Jun 25
http://annals.org/article.aspx?articleid=1700383
"Recommendation: The USPSTF recommends screening for HCV infection in persons at high risk for infection. The USPSTF also recommends offering 1-time screening for HCV infection to adults born between 1945 and 1965. (B recommendation)"
Annals Jun 25
http://annals.org/article.aspx?articleid=1700383
"Recommendation: The USPSTF recommends screening for HCV infection in persons at high risk for infection. The USPSTF also recommends offering 1-time screening for HCV infection to adults born between 1945 and 1965. (B recommendation)"
Friday, June 28, 2013
"Changes in Plaque Lipid Content After Short-Term Intensive Versus Standard Statin Therapy"
JACC July 2013
http://content.onlinejacc.org/article.aspx?articleid=1686313
"Conclusions Short-term intensive statin therapy may reduce lipid content in obstructive lesions. These hypothesis-generating findings warrant confirmation in larger studies with longer follow-up."
JACC July 2013
http://content.onlinejacc.org/article.aspx?articleid=1686313
"Conclusions Short-term intensive statin therapy may reduce lipid content in obstructive lesions. These hypothesis-generating findings warrant confirmation in larger studies with longer follow-up."
Thursday, June 27, 2013
"Sex Differences in the Effectiveness of Early Coronary Computed Tomographic Angiography Compared With Standard Emergency Department Evaluation for Acute Chest Pain"
Circ May/Jun 2013
http://circ.ahajournals.org/content/127/25/2494.abstract
"Conclusions—This trial provides data supporting an early CCTA strategy as an attractive option in women presenting to the ED with symptoms suggestive of acute coronary syndrome. The findings may be explained by lower CAD prevalence and severity in women than men."
Circ May/Jun 2013
http://circ.ahajournals.org/content/127/25/2494.abstract
"Conclusions—This trial provides data supporting an early CCTA strategy as an attractive option in women presenting to the ED with symptoms suggestive of acute coronary syndrome. The findings may be explained by lower CAD prevalence and severity in women than men."
Wednesday, June 26, 2013
"Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial"
Lancet Jun 21
http://www.lancet.com/journals/laneur/article/PIIS1474-4422(13)70130-3/fulltext
"Interpretation
Lancet Jun 21
http://www.lancet.com/journals/laneur/article/PIIS1474-4422(13)70130-3/fulltext
"Interpretation
IST-3 provides evidence that thrombolysis with intravenous alteplase for acute ischaemic stroke does not affect survival, but does lead to statistically significant, clinically relevant improvements in functional outcome and health-related quality of life that are sustained for at least 18 months."
Tuesday, June 25, 2013
"Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis"
BMJ Jun 2013
http://www.bmj.com/content/346/bmj.f3443
"Conclusions Daily prenatal use of iron substantially improved birth weight in a linear dose-response fashion, probably leading to a reduction in risk of low birth weight. An improvement in prenatal mean haemoglobin concentration linearly increased birth weight."
BMJ Jun 2013
http://www.bmj.com/content/346/bmj.f3443
"Conclusions Daily prenatal use of iron substantially improved birth weight in a linear dose-response fashion, probably leading to a reduction in risk of low birth weight. An improvement in prenatal mean haemoglobin concentration linearly increased birth weight."
Sunday, June 23, 2013
"Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus"
NEJM Jun 19
http://www.nejm.org/doi/full/10.1056/NEJMoa1306742?query=featured_home
"CONCLUSIONS
NEJM Jun 19
http://www.nejm.org/doi/full/10.1056/NEJMoa1306742?query=featured_home
"CONCLUSIONS
Person-to-person transmission of MERS-CoV can occur in health care settings and may be associated with considerable morbidity. Surveillance and infection-control measures are critical to a global public health response"
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