BMJ - "Diagnostic prediction models for suspected pulmonary embolism: systematic review and independent external validation in primary care"

"Diagnostic prediction models for suspected pulmonary embolism: systematic review and independent external validation in primary care"

"Conclusions
Five diagnostic pulmonary embolism prediction models that are easily applicable in primary care were validated in this setting. Whereas efficiency was comparable for all rules, the Wells rules gave the best performance in terms of lower failure rates."

http://www.bmj.com/content/351/bmj.h4438 

NEJM - "Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy"

"Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy"

"CONCLUSIONS

Patients with takotsubo cardiomyopathy had a higher prevalence of neurologic or psychiatric disorders than did those with an acute coronary syndrome. This condition represents an acute heart failure syndrome with substantial morbidity and mortality. (Funded by the Mach-Gaensslen Foundation and others; ClinicalTrials.gov number,NCT01947621.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1406761

JAMA - "Association Between Blood Pressure Control and Risk of Recurrent Intracerebral Hemorrhage"

"Association Between Blood Pressure Control and Risk of Recurrent Intracerebral Hemorrhage"

"Conclusions and Relevance  In this observational single-center cohort study of ICH survivors, reported BP measurements suggesting inadequate BP control during follow-up were associated with higher risk of both lobar and nonlobar ICH recurrence. These data suggest that randomized clinical trials are needed to address the benefits and risks of stricter BP control in ICH survivors."

http://jama.jamanetwork.com/article.aspx?articleid=2432164

Weekly Guideline - 2015 "NASPGHAN Guideline for the Diagnosis and Treatment of Celiac Disease in Children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition"

"Guideline for the Diagnosis and Treatment of Celiac Disease in Children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition"

http://www.naspghan.org/files/documents/pdfs/cme/jpgn/Management_of_Ingested_Foreign_Bodies_in_Children_.28.pdf

CIRC - "Extracranial Systemic Embolic Events in Patients With Nonvalvular Atrial Fibrillation"

"Extracranial Systemic Embolic Events in Patients With Nonvalvular Atrial Fibrillation"

"Conclusions—SEE constituted 11.5% of clinically recognized thromboembolic events in patients with atrial fibrillation and was associated with high morbidity and mortality. SEE mortality was comparable to that of ischemic stroke and varied by anatomic site."


http://circ.ahajournals.org/content/132/9/796.abstract 

BMJ - "Safety and efficacy of digoxin: systematic review and meta-analysis of observational and controlled trial data"

"Safety and efficacy of digoxin: systematic review and meta-analysis of observational and controlled trial data"

"Conclusions Digoxin is associated with a neutral effect on mortality in randomised trials and a lower rate of admissions to hospital across all study types. Regardless of statistical analysis, prescription biases limit the value of observational data."

http://www.bmj.com/content/351/bmj.h4451 

NEJM - "Screening for Occult Cancer in Unprovoked Venous Thromboembolism"

"Screening for Occult Cancer in Unprovoked Venous Thromboembolism"

"CONCLUSIONS

The prevalence of occult cancer was low among patients with a first unprovoked venous thromboembolism. Routine screening with CT of the abdomen and pelvis did not provide a clinically significant benefit. (Funded by the Heart and Stroke Foundation of Canada; SOME ClinicalTrials.gov number, NCT00773448.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1506623