NEJM - Cost-Effectiveness of CT Screening for Lung CA

"Cost-Effectiveness of CT Screening in the National Lung Screening Trial"

"CONCLUSIONS

We estimated that screening for lung cancer with low-dose CT would cost $81,000 per QALY gained, but we also determined that modest changes in our assumptions would greatly alter this figure. The determination of whether screening outside the trial will be cost-effective will depend on how screening is implemented. (Funded by the National Cancer Institute; NLST ClinicalTrials.gov number,NCT00047385.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1312547?query=featured_home

JAMA - Nonobstructive CAD and MI Risk

 "Nonobstructive Coronary Artery Disease and Risk of Myocardial Infarction"

"Conclusions and Relevance  In this cohort of patients undergoing elective coronary angiography, nonobstructive CAD, compared with no apparent CAD, was associated with a significantly greater 1-year risk of MI and all-cause mortality. These findings suggest clinical importance of nonobstructive CAD and warrant further investigation of interventions to improve outcomes among these patients."

http://jama.jamanetwork.com/article.aspx?articleid=1920971

Weekly Guideline - 2014 AHA/ASA Prevention of Stroke

"AHA/ASA Guideline Guidelines for the Primary Prevention of Stroke"

http://stroke.ahajournals.org/content/early/2014/10/28/STR.0000000000000046

CIRC - Endocarditis Outcomes

"Long-Term Clinical Outcome of Major Adverse Cardiac Events in Survivors of Infective Endocarditis"

"Conclusion—Despite treatment, the risk of long-term major adverse cardiac events was substantially increased in IE survivors."

http://circ.ahajournals.org/content/130/19/1684.abstract

BMJ - Milk and Fractures in Men & Women

"Milk intake and risk of mortality and fractures in women and men: cohort studies"

"Conclusions High milk intake was associated with higher mortality in one cohort of women and in another cohort of men, and with higher fracture incidence in women. Given the observational study designs with the inherent possibility of residual confounding and reverse causation phenomena, a cautious interpretation of the results is recommended."


http://www.bmj.com/content/349/bmj.g6015

NEJM - Ebola

"Clinical Illness and Outcomes in Patients with Ebola in Sierra Leone"

"CONCLUSIONS

The incubation period and case fatality rate among patients with EVD in Sierra Leone are similar to those observed elsewhere in the 2014 outbreak and in previous outbreaks. Although bleeding was an infrequent finding, diarrhea and other gastrointestinal manifestations were common. (Funded by the National Institutes of Health and others.)"

http://www.nejm.org/doi/full/10.1056/NEJMoa1411680?query=featured_home

JAMA - Dalteparin vs Unfractionated Heparin for the Prevention of VTE

"Cost-effectiveness of Dalteparin vs Unfractionated Heparin for the Prevention of Venous Thromboembolism in Critically Ill Patients"

"Conclusions and Relevance  From a health care payer perspective, the use of the LMWH dalteparin for VTE prophylaxis among critically ill medical-surgical patients was more effective and had similar or lower costs than the use of UFH. These findings were driven by lower rates of pulmonary embolus and heparin-induced thrombocytopenia and corresponding lower overall use of resources with LMWH."

http://jama.jamanetwork.com/article.aspx?articleid=1921813