Thursday, April 11, 2013

"Combination Antifungal Therapy for Cryptococcal Meningitis"  
NEJM April 10
http://www.nejm.org/doi/full/10.1056/NEJMoa1110404?query=featured_home 
"CONCLUSIONS

Amphotericin B plus flucytosine, as compared with amphotericin B alone, is associated with improved survival among patients with cryptococcal meningitis. A survival benefit of amphotericin B plus fluconazole was not found. (Funded by the Wellcome Trust and the British Infection Society; Controlled-Trials.com number, ISRCTN95123928.)"

Wednesday, April 10, 2013

"Long QT Syndrome–Associated Mutations in Intrauterine Fetal Death"
JAMA April 10
http://jama.jamanetwork.com/article.aspx?articleid=1677373
"Conclusions and Relevance  In this molecular genetic evaluation of 91 cases of intrauterine fetal death, missense mutations associated with LQTS susceptibility were discovered in 3 cases (3.3%) and overall, genetic variants leading to dysfunctional LQTS-associated ion channels in vitro were discovered in 8 cases (8.8%). These preliminary findings may provide insights into mechanisms of some cases of stillbirth."

Monday, April 8, 2013

"Effect of Metoprolol Versus Carvedilol on Outcomes in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy)" 
JACC April 2013
http://content.onlinejacc.org/article.aspx?articleid=1673446

Sunday, April 7, 2013

"Management of Patients With Atrial Fibrillation
(Compilation of 2006 ACCF/AHA/ESC and 2011 ACCF/AHA/HRS Recommendations)"
Circ April 1
http://circ.ahajournals.org/content/early/2013/04/01/CIR.0b013e318290826d.full.pdf+html

"Use of Glucocorticoids and Risk of Venous Thromboembolism"
JAMA IM April 1
http://archinte.jamanetwork.com/article.aspx?articleid=1673744

Friday, April 5, 2013

"Individual- Versus Group-Based Financial Incentives for Weight Loss"
Annals Int Med April 2
http://annals.org/article.aspx?articleid=1671710

Thursday, April 4, 2013

"Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study"
Lancet April 2013
http://www.lancet.com/journals/laneur/article/PIIS1474-4422(13)70044-9/fulltext

Wednesday, April 3, 2013

"Clinical prediction model to aid emergency doctors managing febrile children at risk of serious bacterial infections: diagnostic study" 
BMJ Mar 1
http://www.bmj.com/content/346/bmj.f1706